19-去甲睾酮对性腺发育不良小鼠附性腺生长的影响

Effects of 19-nortestosterone on Sex Accessory Gland Growth in Hypogonadal Mice

目的 :观察合成同化甾体激素 19 去甲睾酮 (NT)对性腺发育不良 (hpg)小鼠的前列腺、精囊腺 (SV)、附睾生长发育的影响 ,为用药的安全性提供实验依据。 方法 :NT硅胶囊皮下埋植 5周缓释给药 ,设给药hpg小鼠实验组 (n =7)、不给药hpg小鼠对照组 (n =7)和性腺发育正常小鼠对照组 (n =10 )。给药结束后测定前列腺腹侧叶(VP)、SV和附睾的重量及VP腺管末梢数目。 结果 :与hpg小鼠对照组相比 ,hpg小鼠给药组各附性腺的重量均显著增加 (P <0 .0 0 5 ) ,VP腺管分支形态发育趋于正常 ;hpg小鼠给药组SV的重量与正常小鼠相同 ,但VP、附睾的重量及VP腺管末梢数目仍显著低于正常性腺小鼠对照组 (P <0 .0 0 5 )。 结论

Objectives: To evaluate the effects of 19 nortestosterone (NT) on the growth and development of the ventral prostate (VP), epididymis,and seminal vesicles (SV) in hypogonadal (hpg) mice. Methods: The silastic tube filled with NT was implanted subdermally into mature hpg mice ( n =7) for five weeks. Similar silastic tubes without NT were implanted into both of hpg mouse control group ( n =7) and normal mouse group ( n =10) instead. The weights of sex accessory glands and the branch tip number of VP from all mice were evaluated . Results: The weights of VP, SV,and epididymis in NT treated hpg group were significantly higher than those of hpg control group ( P <0.005); and the branching morphology of the VP showed a tendency to be normal and the development of prostate ductal tip was improved significantly. Especially,the weight of SV in NT treated hpg mice was equal to that of normal mice,while the weights of VP, epididymis and branching tip number in NT treated hpg group was still significantly lower than that of normal mice ( P <0.005). Conclusions: The NT treatment significantly stimulates the growth and development of the sex accessory gland in mature hpg mouse.