BPH病人的逼尿肌超微结构观察

Ultrastructural Observation of Detrusor in BPH Patients

目的 :观察良性前列腺增生 (BPH)病人膀胱逼尿肌超微结构改变 ,探讨BPH病人逼尿肌不稳定和细胞连接之间的关系。 方法 :对BPH病人行尿流动力学检查 ,根据检查结果分为逼尿肌稳定组 (DS)和逼尿肌不稳定组(DI) ,每组 8例 ,取膀胱逼尿肌行光镜、电镜检查。 结果 :DS组逼尿肌细胞间中间连接和胞突连接数分别为 11.34± 3.2 3、4 .2 6± 1.78;DI组细胞间中间连接数显著减少 (3.12± 1.4 7) ,代之以大量的胞突连接 (2 6 .37± 7.14 ) ,与DS组相比 ,差异均有极显著性 (P <0 .0 1)。 结论 :逼尿肌超微结构改变与前列腺增生所致逼尿肌不稳定密切相关 ,逼尿肌超微结构观察 。

Objectives: To observe the detrusor ultrastructure in BPH patients and to investigate the relationship between detrusor instability and ultrastructure. Methods: The patients were divided into groups of detrusor instability(DI) and detrusor stability(DS) according to urodynamics examination. The structure of the detrusor were observed by light microscopy and transmission electron microscopy(TEM). Results: The intercellular intermediate junctions and cytoplasmic process junctions in DS were 11.34±3.23 and 4.26±1.78 respectively. The intercellular intermediate junctions decreased obviously (3.12±1.47, P <0.01)instead of a large amount of cytoplasmic process junctions (26.37±7.14, P <0.01) in DI. Conclusions: There is a close relevance between intercellular junctions and DI. The observation of the ultrastructure of the detrusor is helpful for the diagnosis of BPH with DI and for the clinical treatment.