2型糖尿病增生性视网膜病变患者血管内皮生长因子及炎症介质水平改变的临床研究

The changes and clinical value of VEGF and inflammatory indexes for patients with type 2 diabetes mellitus combined with proliferative diabetic retinopathy

目的分析2型糖尿病增生性糖尿病视网膜病变(PDR)患者血管内皮生长因子(VEGF)及炎症介质水平的改变和临床意义。方法纳入分析2015年1月至2017年1月在我院接受诊疗的2型糖尿病患者的临床资料。依据患者是否并发DR分为观察组(合并)及对照组(不合并)。共纳入观察组患者46例,对照组患者51例。检测并对比两组患者外周血相关指标,包括:VEGF、白介素-6(IL-6)、白介素-10(IL-10)及C-反应蛋白(CRP);对比两组生化指标,包括:糖化血红蛋白(Hb A1c)、甘油三脂(TG)及总胆固醇(TC)。分析观察组患者VEGF水平与其他指标间的相关性。结果观察组患者外周血VEGF及IL-6水平均显著高于对照组患者(P<0.05)。两组患者外周血IL-10及CRP水平比较未见显著差异(P>0.05)。观察组患者Hb A1c显著高于对照组患者(P<0.05)。两组患者TC及TG水平比较未见显著差异(P>0.05)。观察组患者外周血VEGF水平与IL-6(r=0.713,P<0.01)及HbA1c(r=0.675,P<0.01)均呈现显著正相关关系。结论 2型糖尿病PDR患者外周血VEGF水平显著升高,可能与促炎介质及高血糖共同促进眼部病变。

Objective To analyze the changes and clinical value of VEGF and inflammatory indexes for patients with type 2 diabetes mellitus combined with proliferative diabetic retinopathy. Methods Clinical data of patients with type2 diabetes received treatment at our hospital from 2015 to 2017 were analyzed as group A. Patients were divided into two groups by whether suffered from proliferative retinopathy,group A： yes and group B： no. Results A total of 97 patients were analyzed,group A 46 cases,group B 51 cases. group A patients had higher levels of VEGF,IL-6 and Hb A1 c than these of group B patients,the difference was statistically significant（ P〈0. 05）. There was no significant difference of IL-10,CRP,TC and TG between the two groups（ P〉0. 05）. Correlation analysis showed that,for Group A patients,the levels of VEGF had significant negative correlation with IL-6（ r = 0. 713,P〈0. 01） and HbA1c（ r = 0. 675,P〈0. 01）.Conclusions VEGF was increased in type 2 diabetes patients with proliferative diabetic retinopathy,which showed internal relation with inflammation and blood-sugar control condition.