放射性核素^131Ⅰ在甲亢治疗中的安全性与有效性分析

Safety and Efficacy Analysis of Radionuclide ^(131)Ⅰ in the Treatment of Hyperthyroidism

目的分析放射性核素^(131)Ⅰ在甲亢治疗中的安全性与有效性。方法回顾性分析2015年8月~2017年8月本院收治的64例甲亢患者,按照随机数字表法将其分为实验组和对照组,各32例,对照组患者给予丙硫氧嘧啶片治疗,实验组患者给予丙硫氧嘧啶片+^(131)Ⅰ治疗,观察两组患者的治疗总有效率、不良反应发生率、FT_3、FT_4及TSH变化水平。结果实验组临床总有效率87.50%高于对照组的62.50%,差异有统计学意义(P<0.05);实验组不良反应发生率3.75%低于对照组31.25%,差异有统计学意义(P<0.05);治疗后,实验组患者FT_3、FT_4、TSH水平均优于对照组,差异有统计学意义(P<0.05)。结论放射性核素^(131)Ⅰ在甲亢治疗中可有效提高治疗效果,改善患者FT_3、FT_4及TSH水平,不良反应少。

Objective To analyze the safety and efficacy of radionuclide ^131I in the treatment of hyperthyroidism. Methods A retrospective analysis of 64 patients with hyperthyroidism admitted to our hospital from August 2015 to August 2017 was divided into experimental group and control group according to the random number table method,32 cases in each group.Patients in the control group were treated with propylthiouracil tablets.Patients in the experimental group were treated with propylthiouracil tablets ＋^131I.The total effective rate,adverse reaction rate,FT3,FT4 and TSH levels were observed in the two groups.Results The total effective rate of the experimental group was 87.50% higher than that of the control group 62.50%,the difference was statistically significant（ P〈0.05）. The incidence of adverse reactions in the experimental group was 3.75% lower than that in the control group 31.25%,the difference was statistically significant（P〈0.05）;After treatment,the FT3,FT4,and TSH levels in the experimental group were better than those in the control group,and the difference was statistically significant（P〈0.05）.Conclusion Radionuclide ^131I can effectively improve the therapeutic effect in the treatment of hyperthyroidism,improve the levels of FT3,FT4 and TSH in patients with less adverse reactions.