多奈哌齐联合司来吉兰对帕金森病患者的疗效及安全性分析

Analysis of Effect and Safety of Donepezil Combined with Selegiline in Patients with Parkinson's Disease

目的研究多奈哌齐联合司来吉兰对帕金森病(PD)患者简易精神状态量表(MMSE)评分及生活质量的影响。方法选取2016年3月~2017年5月武陟县中医院收治的92例PD患者,按照随机数字表法分为两组。对照组46例给予司来吉兰治疗,观察组46例给予多奈哌齐联合司来吉兰治疗。对比两组治疗效果、治疗前后MMSE评分、蒙特利尔认知评估量表(MoCA)评分、生活质量评分以及不良反应发生情况。结果观察组治疗总有效率较对照组高,差异有统计学意义(P<0.05);治疗后,观察组MMSE、MoCA评分较对照组高,差异有统计学意义(P<0.05);治疗后,观察组简明健康状况量表(SF-36)评分高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率与对照组相比,差异无统计学意义(P>0.05)。结论多奈哌齐联合司来吉兰治疗PD具有显著效果,可改善患者精神状态与认知能力,提高生活质量,安全性较好。

Objective To investigate the effect of donepezil combined with selegiline on MMSE score and quality of life in patients with Parkinson＇s disease. Methods A total of 92 patients with PD from March 2016 to May 2017 in Wuzhi County Hospital of traditional Chinese Medicine were randomly divided into two groups. The control group（46 cases） was treated with donepezil, and the observation group（46 cases） was treated with donepezil combined with selegiline. The treatment effect, adverse reaction, MMSE score, Montreal cognitive assessment scale（Mo CA） score and quality of life score in two groups before and after treatment were compared. Results The total effective rate of the observation group was higher than that of the control group（P〈0.05）. After treatment, the scores of MMSE and Mo CA in the observation group were higher than those in the control group（P〈0.05）. After treatment, the simple health status scale（SF-36） score of the observation group was higher than that of the control group（P〈0.05）. There was insignificant difference in the incidence of adverse reactions between the observation group and the control group（P〉0.05）. Conclusion The effect of donepezil combined with selegiline in the treatment of PD is significant. It can improve the mental status and cognitive ability of patients and improve the quality of life with better safety.