低血糖与胰岛素治疗关系之再探讨

Rediscussion about the Relationship between Hypoglycemia and Insulin

低血糖是糖尿病患者降糖治疗过程中常见的不良事件,是糖尿病患者长期维持正常血糖水平的制约因素。一次严重的医源性低血糖或由此诱发的心血管事件可能会抵消一生维持血糖在正常范围内所带来的益处。因此,关注和重视低血糖是临床治疗及胰岛素研发的重点。理想的基础胰岛素期望达到作用长效、变异性低,平稳有效降糖、低血糖风险少的效果。本文将对低血糖标准更新再次解读,从低血糖的影响因素、对于机体的危害等方面探索更为安全有效的胰岛素治疗方案,以期为临床管理提供更多选择。

Hypoglycemia contributed to common adverse event in antihyperglycemic management and became major limiting factor to maintain long-term euglycemia in patients with diabetes. Only once serious iatrogenic hypoglycemia or following cardiovascular accident could counteract benefit from lifetime glucose maintenance in normal range. Thus, concern and attention would be paid on clinical therapy, research and development for insulin. Optimal insulin referred to long-acting duration, low variability and steady glucose-lowering characteristics with less hypoglycemia. This article would review the updated diagnostic criteria of hypoglycemia, and explore more effective and safer strategy of insulin therapy in terms to influencing factors and hazard of hypoglycemia. It was expected to provide more alterative for clinical management.