丹参川芎嗪联合利舒康胶囊治疗腔隙性脑梗死眩晕的疗效及对患者血清同型半胱氨酸水平的影响

Effect of Salvia Miltiorrhiza-Salvia Miltiorrhiza-Ligustrazine Injection and Lishukang on Vertigo Induced by Lacunar Infarction and Its Effect on Serum Homocysteine in Patients

目的：评价丹参川芎嗪联合利舒康胶囊治疗腔隙性脑梗死眩晕的疗效及对患者血清同型半胱氨酸（Hcy）水平的影响。方法：将2015年3月—2017年3月在本院接受治疗的100例腔隙性脑梗死眩晕患者作为研究对象,根据双盲法分为两组。联合组50例,联合丹参川芎嗪与利舒康胶囊治疗;对照组50例,单用利舒康胶囊治疗。观察两组治疗前、后血清Hcy水平、脑血流速度、眩晕发作情况及美国国立卫生院神经功能缺损评分（NIHSS）变化,并将两组临床疗效及用药安全性展开对比。结果：联合组治疗总有效率与对照组相比较高[92.00%（46/50）VS 74.00%（37/50）],差异有统计学意义（P〈0.05）;联合组治疗后血清Hcy水平较对照组低,左椎动脉、右椎动脉、基底动脉血流速度较对照组高,差异有统计学意义（P〈0.05）;联合组治疗后NIHSS评分、眩晕次数及持续时间均较对照组低,差异有统计学意义（P〈0.05）;所有患者治疗期间均未见肝肾功能受损、药物过敏等严重不良反应。结论：给予腔隙性脑梗死眩晕患者丹参川芎嗪联合利舒康胶囊治疗效果确切,利于降低血清Hcy水平,减轻或消除临床症状,改善脑血流状况,促进神经功能恢复,利于预后,且安全可靠。

Objective：To evaluate the curative effect of Salvia Miltiorrhiza-Ligustrazine Injection and Lishukang Capsule on patients with dizziness caused by lacunar infarction and its effect on serum homocysteine（ Hcy） level. Methods：A hundred cases of lacunar infarction patients with vertigo treated in our hospital from March 2015 to March 2017 were divided into two groups according to double-blind method. Fifty cases of patients in the control group were treated with Lishukang Capsule. And 50 cases of patients in combination group were given Salvia Salvia Miltiorrhiza-Ligustrazine Injection combined with Lishukang Capsule for treatment. The levels of serum Hcy,cerebral blood flow velocity,dizziness and neurological deficit score（ NIHSS） in the two groups before and after treatment were observed. The clinical efficacy and safety of the two groups were compared. Results：The total effective rate of the combination group was higher than that of the control group [92. 00%（46/50） vs 74. 00%（37/50）],and the difference was statistically significant（ P〈0. 05）. The serum Hcy levels in the combination group were lower than those in the control group,and the left vertebral artery,right vertebral artery and basilar artery blood flow velocity were higher than those in the control group（ P〈0. 05）. The NIHSS score,dizziness frequency and duration of the combination group were lower than those of the control group after treatment,and the difference was statistically significant（ P〈0. 05）. All the patients during treatment showed no liver and kidney dysfunction,drug allergies or other serious adverse reactions. Conclusion：For patients with lacunar infarction dizziness,Salvia Miltiorrhiza-Ligustrazine Injection combined with Lishukang Capsule treatment has exact effect and will help to reduce serum Hcy levels,reduce or eliminate clinical symptoms,improve cerebral blood flow,and promote neurological recovery. The treatment is safe and reliable.