补肾活血益精方治疗特发性弱畸精子症疗效观察

Effect of Kidney-invigorated and Invigorated Blood Treatment of Idiopathic Hypoteratosis

目的：观察经验方补肾活血益精方治疗特发性弱畸精子症临床疗效并作出客观评价。方法：将60例弱畸精子症患者随机分为治疗组（30例,补肾活血益精方）和对照组（30例,五子衍宗丸）,连续治疗13周,治疗前后每位患者均检测精液质量主要参数、精子形态及精浆α-葡糖苷酶活性（速率法）;疗程结束后1个月随访患者妊娠情况。结果：治疗组治疗前后比较,精子PR百分率、精子存活率、精子正常形态百分率、精浆α-葡糖苷酶活性、精子头部缺陷百分率差异均有显著性统计学意义（Z分别为-5.226、-4.798、-6.328、-4.147、-3.548,均P〈0.01）;对照组治疗前后比较,精子PR百分率差异有显著性统计学意义（t=0.020,P〈0.01）,精子存活率、精子正常形态百分率、精浆α-葡糖苷酶活性、胞浆小滴百分率差异均有显著性统计学意义（Z分别为-2.883、-5.796、-3.193、-2.849,均P〈0.01）,精子头部缺陷百分率有统计学差异（Z=-2.210,P〈0.05）。治疗后治疗组与治疗后对照组比较,精子PR百分率差异有统计学意义（t=0.694,P〈0.05）,精子存活率、精子正常形态百分率差异也有统计学意义（Z分别为-2.011、-2.248,均P〈0.05）,胞浆小滴百分率比较有显著性统计学意义（Z=-2.640,P〈0.01）。其余各组比较均无统计学差异。两组受试者疗效比较,治疗组与对照组比较差异虽无统计意义（χ2=1.002,P=0.317〉0.05）,但治疗组明显高于对照组。结论：补肾活血益精方治疗特发性弱畸精子症具有一定疗效,其药理机制仍需进一步探讨。

Objective：To observe the clinical efficacy and objective evaluation of the treatment of idiopathic hypodetic sperms.Methods：Sixty patients with weak abnormal sperm were randomly divided into treatment group（ 30 cases,Bushen Huoxeu Yijing Formula） and the control group（30 cases,Wuzi Yanzong Pills）. The treatment lasted for 13 weeks. Before and after treatment,we detected the main parameters inclulding semen quality,sperm morphology and seminal plasma of alpha glucoside enzyme activity（rate）. The pregnancy was followed by 1 month after treatment. Results：Before and after treatment,sperm percentage PR,sperm survival rate,normal sperm morphology percent,seminal plasma of alpha glucoside enzyme activity and sperm head defect percentage had significant statistical significance（ Z = respectively 5. 226,4. 798,6. 328,4. 147,3. 548,P〈0. 01）. Before and after treatment,sperm percentage PR had significant difference（ t = 0. 020,P〈0. 01）. The sperm survival rate,normal sperm morphology percent and seminal plasma of alpha glucoside enzyme activity and cytoplasm droplets percentage had statistical significance（ Z =2. 883,5. 796,3. 193,2. 849,P〈0. 01）. The sperm head defect percentage was statistically different（ Z = 2. 210,P〈0. 05）. After treatment,the treatment group＇ s sperm PR percentage compared with that of control group was statistically significant（ t =0. 694,P〈0. 05）. The sperm survival rate and normal sperm morphology percent had statistical significance（ Z = 2. 011,2. 248,P〈0. 05）. The cytoplasm small percentage drops had statistical significance（ Z = 2. 640,P〈0. 01）. There was no statistical difference in the remaining groups. The comparison between the two groups was not statistically significant（ Z = 1. 002,P = 0. 317,P〈0. 05）. But the treatment group＇s was significantly higher than that of the control group. Conclusion：The pharmacological mechanism of the treatment of idiopathic hypoteratogenous spermatozoa has some curative effect.