慢性阻塞性肺疾病急性加重辨证分型与炎症因子的相关性研究

Study of Correlation of Acute Exacerbation of Chronic Obstructive Pulmonary Disease Syndrome Differentiation and Inflammatory Factors

目的：观察慢性阻塞性肺疾病急性加重（AECOPD）不同辨证分型与炎症因子的关系,为中医辨证分型提供客观指标。方法：选取符合AECOPD诊断标准和肺胀中医辨证标准的患者进行辨证分型,以健康组为对照组,检测患者治疗前血清降钙素原（PCT）、C-反应蛋白（CRP）、白细胞（WBC）、白细胞介素-6（IL-6）水平,观察各证型组间差异性以及炎症指标与证型组别间的相关性。结果：AECOPD不同中医证型患者的血清的CRP水平差异存在统计学意义,血清PCT与证型分型存在相关性。结论：可尝试将血清PCT、CRP、IL-6等作为AECOPD中医辨证分型的客观依据,推进中医辨证分型的客观统一。

Objective：To observe the relationship between different AECOPD syndrome differentiation and inflammatory factors,offering objective index for syndrome differentiation of TCM. Methods：Patients conforming to AECOPD diagnostic standard and lung inflation syndrome differentiation of TCM standard were chosen for syndrome differentiation and healthy patients were as control group. PCT,CRP,WBC and IL-6 levels of the patients before surgery were examined. Syndrome difference in each group and correlation between inflammatory index and syndrome types were observed. Results： Serum CRP level difference of patients with different AECOPD syndrome differentiation of TCM was of statistical significance and serum PCT and syndrome differentiation were correlated. Conclusion：Serum PCT,CRP and IL-6 can be used as objective trial basis for AECOPD syndrome differentiation of TCM,promoting the objective unification of syndrome differentiation of TCM.