奥美拉唑为基础的三联疗法对幽门螺杆菌感染胃溃疡患者血清炎症因子及胃肠激素的影响

Effects of omeprazole-based triple therapy on serum inflammatory factors and gastrointestinal hormones in patients with Helicobacter pylori-infected gastric ulcer

目的探讨以奥美拉唑为基础的三联疗法对幽门螺杆菌感染胃溃疡患者血清炎症因子及胃肠激素的影响。方法选取2015年11月~2017年10月我院收治的幽门螺杆菌感染胃溃疡患者84例,采用随机数字表法将其分为参照组、实验组,每组42例。参照组采用奥美拉唑和阿莫西林治疗,实验组采用奥美拉唑为基础的三联疗法治疗。比较两组病患的治疗效果以及血清炎症因子和胃肠激素水平的变化。结果实验组患者的总有效率明显高于参照组,差异有统计学意义(P<0.05)。治疗前,两组患者的血清炎症因子水平比较,差异均无统计学意义(P>0.05);治疗后,两组患者的血清炎症因子水平均低于治疗前,且实验组患者血清炎症因子水平均显著低于参照组,差异均有统计学意义(P<0.05)。治疗前,两组患者胃肠激素水平比较,差异均无统计学意义(P>0.05);治疗后,两组患者的胃肠激素水平均低于治疗前,且实验组患者的胃肠激素水平均显著低于参照组,差异均有统计学意义(P<0.05)。结论在幽门螺杆菌感染胃溃疡患者的治疗中采用奥美拉唑为基础的三联疗法治疗,可有效改善其血清炎症因子和胃肠激素指标水平,有利于溃疡的痊愈。

Objective To investigate the effect of omeprazole-based triple therapy on serum inflammatory factors and gastrointestinal hormones in patients with Helicobacter pylori-infected gastric ulcer. Methods A total of 84 patients with Helicobacter pylori-infected gastric ulcer admitted to our hospital from November 2015 to October 2017 were selected and divided into reference group and experimental group by random number table method, with 42 cases in each group.The reference group was treated with omeprazole and amoxicillin, while the experimental group was treated with omeprazole-based triple therapy.The therapeutic effects of the two groups of patients, as well as the changes of serum inflammatory factors and gastrointestinal hormone levels were studied and compared. Results The total effective rate in the experimental group was significantly higher than that in the reference group, the differences were statistically significant（P〈0.05）. Before treatment, there was no significant difference between the two groups（P〈0.05）. After treatment,the levels of serum inflammatory factors in the two groups were lower than those before treatment, and the levels of serum inflammatory factors in the experimental group were significantly lower than those in the reference group, the differences were statistically significant（P〈0.05）. Before treatment, there was no statistically significant difference in gastrointestinal hormone levels between the two groups before and after treatment（P〈0.05）. After treatment, the gastrointestinal hormone levels in the two groups were lower than those before treatment, and the gastrointestinal hormone levels in the experimental group were significantly lower than those in the reference group, the differences were statistically significant（P〈0.05）. Conclusion Omeprazole-based triple therapy can effectively improve the levels of serum inflammatory factors and gastrointestinal hormone in the treatment of patients with Helicobacter pylori-infected gastric ulcer, which is beneficial to the recovery of the ulcer.