磷酸奥司他韦治疗乙型小儿流行性感冒的临床效果

Clinical effect of Oseltamivir Phosphate in the treatment of children with influenza B

目的探讨磷酸奥司他韦治疗乙型小儿流行性感冒的临床效果。方法选取2016年10月~2017年10月我院儿科收治的60例乙型小儿流行性感冒患儿作为研究对象,将其随机分为对照组和观察组,每组各30例。对照组患儿采用常规治疗,观察组患儿在对照组基础上给予磷酸奥司他韦治疗。比较两组患儿的临床疗效、各项症状改善时间、炎性因子水平变化及不良反应发生情况。结果观察组患儿的治疗总有效率为93.33%,明显高于对照组的76.67%,差异有统计学意义(P<0.05)。观察组患儿治疗后的干咳改善时间、咽干喉痛消退时间、体温恢复正常时间、治疗时间均明显短于对照组,差异均有统计学意义(P<0.05)。两组患儿治疗后的IFN-γ、IL-6、TNF-α水平均明显低于治疗前,差异均有统计学意义(P<0.05);观察组患儿治疗5 d后的IFN-γ、IL-6、TNF-α水平均低于对照组,差异均有统计学意义(P<0.05)。两组患儿的腹痛、腹泻、恶心呕吐等胃肠道不良反应发生率比较,差异无统计学意义(P>0.05)。结论磷酸奥司他韦治疗乙型小儿流行性感冒的效果显著,有利于患儿症状的快速改善,促进炎症消退,缩短治疗时间,且使用安全性高,具有积极的临床意义。

Objective To investigate the clinical effect of Oseltamivir Phosphate in the treatment of children with influenza B. Methods A total of 60 children with influenza B from October 2016 to October 2017 treated in the department of pediatrics of our hospital were selected as research objects and randomly divided into the control group and the observation group, with 30 cases in each group. The control group was treated with routine therapy, while the observation group was treated with Oseltamivir Phosphate on the basis of the control group. The clinical efficacy, time of symptom improvement, level changes of inflammatory factors and adverse reactions were compared between two groups. Results The total effective rate of the observation group was 93.33%, which was significantly higher than that of the control group（76.67%）, and the difference was statistically significant（P〈0.05）. The improvement time of dry cough, the remission time of sore throat, the normal time of body temperature recovery and the time of treatment in the observation group after treatment were significantly shorter than those in the control group,and the differences were statistically significant（P〈0.05）. The levels of IFN-γ, IL-6 and TNF-α in two groups after treatment were significantly lower than those before treatment, and the differences were statistically significant（P〈0.05）. The levels of IFN-γ, IL-6 and TNF-α in the observation group 5 d after treatment were significantly lower than those in the control group, and the differences were statistically significant（P〈0.05）. There was no statistically significant difference in the incidence of gastrointestinal adverse reactions such as abdominal pain, diarrhea, nausea and vomiting between two groups（P〈0.05）.Conclusion The effect of Oseltamivir Phosphate in the treatment of infantile influenza B is significant, which is beneficial to the rapid improvement of symptoms, promoting the abatement of inflammation, shortening the time of treatment,and has high safety, with positive clinical significance.