类芽孢杆菌抗菌物质的研究进展

Research progress of antimicrobial substance produced by Paenibacillus

细菌多重耐药性的出现引发了新型抗菌物质的需求。类芽孢杆菌在生长过程中会产生一系列抗菌物质,如Octapeptins,Polypeptins,Pelgipeptin,Fusaricidins和Tridecaptins等,这些抗菌物质对细菌、真菌、肿瘤和病毒有一定的拮抗作用。在过去几年里,人们对类芽孢杆菌来源的抗菌物质的生化特性、作用模式和分离方法进行了广泛地研究。概述了类芽孢杆菌抗菌物质的主要类别、作用机理以及常用的分离纯化方法,最后对类芽孢杆菌抗菌物质的应用前景作了展望。

The emergence of multi-drug resistant bacteria has led to the demand for new antibiotics. In the growth of Paenibacilli,they produce a series of antibacterial substances,such as Octapeptins,Polypeptins,Pelgipeptinnh,Fusaricidins,Tridecaptins,etc. These antimicrobial substances have effects on bacteria,fungi,tumor,virus,etc. and a great number of researches have been undertaken on their physiological characteristics,action patterns and application prospects in the last few years. The main categories,mechanism on indicators and purification methods of the antimicrobial substances produced by Paenibacillus were reviewed. Finally,the application of the antibacterial substances produced by Paenibacillus was prospected.