阴性症状为主的首发精神分裂症患者血清p-mTOR和IL-10水平变化及相关性分析

Change of serum p-mToR and IL-10 levels in first episode schizophrenia patients with predominant negative symptoms and correlation analysis

目的探讨以阴性症状为主的精神分裂症血清磷酸化雷帕霉素靶蛋白(p-mTOR)、白细胞介素10(IL-10)水平变化及其与精神分裂症的相关性。方法采用ELISA测定56例以阴性症状为主的首发未服药精神分裂症和56例健康对照者血清中p-mTOR、IL-10水平,采用阳性与阴性症状量表(PANSS)评定精神分裂症患者症状。结果研究组血清p-mTOR值高于对照组[(4.38±1.30)ng/L vs.(3.88±0.76)ng/L],差异有统计学意义(P<0.05);p-mTOR与PANSS阴性症状评分呈正相关(r=0.283,P<0.05)。而研究组血清IL-10水平与对照组比较差异无统计学意义,但是与PANSS总分呈负相关(r=-0.507,P<0.01)。研究组血清p-mTOR与IL-10水平呈正相关(r=0.437,P=0.001)。健康组血清p-mTOR与IL-10水平呈负相关(r=-0.403,P=0.002)。结论 mTOR信号通路活性增高可能与阴性症状为主精神分裂症的病理机制相关,mTOR活性越高,阴性症状越严重;mTOR信号通路激活后还可能与IL-10水平相关。

Objective To investigate the change of serum p-mTOR and IL-10 levels in the schizophrenia patients with predominant negative symptoms and its correlation with schizophrenia.Methods Serum pmTOR and IL-10 levels were detected in 56 schizophrenia patients with predominant negative symptoms and56 healthy controls by adopting the enzyme linked immunosorbent assay（ELISA）.The schizophrenia symptoms were assessed by adopting the Positive and Negative Syndrome Scale（PANSS）.Results The values of serum p-mTOR in the study group was higher than that in the control group[（4.38±1.30）ng/Lvs.（3.88±0.76）ng/L],the difference was statistically significant（P〈0.05）;the p-mTOR level was positively correlated with the PANSS score（r=0.283,P〈0.05）.The serum IL-10 level had no statistical difference between the study group and control group.And the serum IL-10 level was negatively correlated with the PANSS score（r=-0.507,P〈0.01）.The serum p-mTOR and IL-10 levels in the study group had a positive correlation（r=0.437,P=0.001）.The serum p-mTOR and IL-10 levels in the health group had a negative correlation（r=-0.403,P=0.002）.Conclusion The p-mTOR signal pathway activity increase might be related with the pathological mechanism in the implicated in the schizophrenia patients with predominant negative symptoms.The higher the p-mTOR activity,the severe the negative symptoms.The p-mTOR signal pathway activation might be associated with serum IL-10 level.