乳腺癌C-erB-2、Ki67、P53表达与淋巴结转移的相关性及临床意义研究

Expression of C-erB-2,Ki67 and P53 in Breast Cancer and Its Correlation with Lymph Node Metastasis and Its Clinical Significance

目的探究乳腺癌患者C-er B-2、Ki-67、P53的表达与淋巴结转移的相关性及其临床意义。方法选择2013年7月至2016年6月我院收治的429例经病理学检查确诊为乳腺癌的患者作为研究对象,根据籍贯将其分为观察组(外地患者)136例及对照组(本地患者)293例。比较两组C-er B-2、Ki-67及P53总体阳性率及不同程度阳性率,并对乳腺癌患者C-er B-2、Ki-67、P53的表达与病理类型、肿瘤大小、淋巴结是否转移及TNM分期进行相关性分析。结果两组患者C-er B-2、Ki-67及P53总体阳性率及不同程度阳性率的比较无统计学差异(P>0.05);C-er B-2、Ki-67与淋巴结转移呈正相关(r=0.153,r=0.192;P<0.05)。结论 C-er B-2、Ki-67与乳腺癌患者淋巴结转移呈正相关,有可能成为协助乳腺癌早期诊断,评估患者预后的指标。

Objective To investigate the correlation between the expression of C-erB-2,Ki-67 and P53 and lymph node metastasis in breast cancer patients and its clinical significance.Methods 429 cases of patients who were accepted in our hospital from July 2013 to June 2016 and were pathologically diagnosed with breast cancer,were chosen as the research object,and divided into the observation group（foreign patients）and control group（local patients）according to the origin.The observationgroup have136 cases and the control group have 293 cases.Compared the overall positive rate and different degree of positive rates of C-erB-2,Ki-67,P53 between the two groups,analyzed the correlation between the expression of C-erB-2,Ki-67,P53 in breast cancer patients with pathological types,tumor size,lymph node metastasis and TNM staging.Results There was no significant difference between the two groups in the overall positive rate and different degree of positive rates in C-erB-2,Ki-67 and P53（P0.05）;C-erB-2 and Ki-67 were positively correlated with lymph node metastasis（r=0.153,r=0.192,P0.05）.Conclusion C-erB-2 and Ki-67 are positively related to lymph node metastasis in breast cancer patients,and maybe the markers for earlydiagnosis ofbreast cancer and evaluatingthe prognosis ofpatients.