普通级封闭群裸鼹鼠种群的建立及其生物学特性的研究进展

Establishment of a closed colony of conventional naked mole-rats and progress in research of their biological characteristics

裸鼹鼠具有抗肿瘤、耐低氧、耐疼痛、寿命长等优势特性,引起了国内外广泛关注,其实验动物化及应用推广迫在眉睫。本团队围绕裸鼹鼠实验动物化及标准化开展了系统研究。通过对裸鼹鼠繁殖、遗传、微生物及营养学的研究,解决了了裸鼹鼠繁殖率低下,遗传背景不明确和携带病原微生物不明等问题,成功建立了普通级封闭群裸鼹鼠种群,现种群已繁殖至第6世代。同时对所建立种群生物学特性,如耐低氧、抗肿瘤、抗衰老等开展了系统研究,为相关疾病的研究和药物研发提供了新的动物模型材料和研究策略。

Naked mole-rats（ NMR,Heterocephalus glaber） are a unique species of rodents exhibiting high longevity,tumor resistance,hypoxia tolerance and pain insensitivity. These features make NMRs widely used mammalian models for biomedical research in aging, cancer, neurobiology and other fields. Their laboratory animalization and application are very important. Thus,our research team carried out a systematic study on the establishment of laboratory animalization and standardization of NMRs. Through the study of reproduction,genetics,microbiology and nutrition of NMRs,the difficulties of low reproductive rate,unclear genetic background and unidentified pathogenic microorganisms have been overcome. The population of the ordinary closed NMRs was successfully established,and the present population has been propagated to the sixth generation. At the same time,the biological characteristics of the population have been systematically studied,such as hypoxia tolerance,tumor resistance and longevity,which will provide new strategies for the prevention and treatment for related diseases.