射血分数保留慢性心力衰竭患者撤机困难的危险因素分析

Risk factors for weaning difficulty in patients with chronic heart failure and preserved ejection fraction

目的 探讨射血分数保留慢性心力衰竭患者撤机失败的危险因素.方法 回顾性分析我院收治的126例射血分数保留慢性心力衰竭患者,经呼吸机辅助通气配合药物治疗后,分为撤机成功组（96例）和撤机失败组（30例）,研究撤机失败的相关影响因素.结果 单因素分析结果显示,撤机成功组在糖尿病、高血压、高碳酸血症、TG、Sc、SUA、cTn Ⅰ、NT-proBNP、VE、VE/VA与撤机失败组相比较,差异有统计学意义（P＜0.05）.非条件Logistic回归分析显示,糖尿病、高血压、高碳酸血症、TG、NT-proBNP、VE以及VE/VA为患者撤机失败的危险因素.结论 射血分数保留慢性心力衰竭患者撤机失败的危险因素较多,撤机前需要充分判断撤机时机,从而提高撤机准确性以及改善预后.

Objective To investigate the risk factors of weaning failure in patients with chronic heart failure and preserved ejection fraction.Methods A total of 126 patients with chronic heart failure and preserved ejection fraction hospitalized in our hospital were retrospectively analyzed.The patients received ventilator-assisted ventilation and drug treatment,and were divided into the successful weaning group （n=96） and failed weaning group （n=30）.The associated influencing factors the weaning failure was determined.Results The findings of univariate analysis showed that there were statistically significant differences in diabetes mellitus,hypertension,hypercapnia,TG,Sc,SUA,cTnⅠ,NT-proBNP,VE,and VE/VA between the successful weaning group and failed weaning group （P〈0.05）.The unconditional logistic regression analysis showed that diabetes,hypertension,hypercapnia,TG,NT-proBNP,VE and VE/VA were the risk factors for weaning failure.Conclusion There are many risk factors for the weaning failure in patients with chronic heart failure with preserved ejection fraction.Before weaning,it is necessary to fully judge the weaning time,so as to improve the accuracy of weaning and prognosis.