利培酮和氯氮平对精神分裂症患者血脂代谢的影响

Effects of risperidone and clozapine on blood lipid metabolism in patients with schizophrenia

目的探讨利培酮和氯氮平对精神分裂症患者糖脂代谢的影响。方法选择2016年1月至2017年6月本院精神心理科精神分裂症患者100例,随机分为利培酮治疗组(试验组)与氯氮平治疗组(对照组),各50例。分别于治疗前、后测定血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和空腹血糖(FBG)水平。结果治疗前,两组各项指标比较无显著性差异(P>0.05)。治疗后,与治疗前比较,两组HDL-C水平无统计学意义(P>0.05);TC、TG、LDL-C、FBG水平、BMI均显著高于治疗前(P<0.01)。治疗后,试验组TC、TG、LDL-C水平及BMI均低于对照组(P<0.01)。结论两种药物均可导致精神分裂症患者产生脂代谢异常,利培酮对脂代谢的影响小于氯氮平。

Objective To explore the effect of risperidone and clozapine on blood lipid metabolism in patients with schizophrenia. Methods A total of 100 patients with schizophrenia of the psychology department from January 2016 to June2017 in our hospital were retrospectively analyzed in this study. They were randomly divided into risperidone-treated group（experimental group） and clozapine-treated group（control group）, with 50 cases in each group. The total cholesterol（TC）,triglyceride（TG）, high-density lipoprotein（HDL-C）, low-density lipoprotein（LDL-C） and fasting blood glucose（FBG）levels were measured before and after treatment. Results There were no significant differences in various indexes between the two groups before treatment（P〈0.05）. After treatment, the levels of HDL-C of the two groups were not different from those before treatment（P〈0.05）; the levels of TC, TG, LDL-C and FBG, BMI of the two groups were significantly higher than those before treatment, the differences were statistically significant（P〈0.01）. After treatment, the levels of TC, TG and LDL-C, BMI in the experimental group were significantly lower than those in the control group（P〈0.01）. Conclusion Risperidone and clozapine can cause abnormal blood lipid metabolism in patients with schizophrenia, and risperidone has less effect on blood glucose and lipid metabolism than clozapine.