老年糖尿病合并肺炎患者不同抗菌方案治疗后的血清学指标变化

Changes of serological indexes after different antimicrobial regimens treatment in elderly diabetic patients complicated with pneumonia

目的分析老年糖尿病合并肺炎患者不同抗菌方案治疗后血清学指标的变化情况。方法回顾性分析80例老年糖尿病合并肺炎患者的临床资料,将43例接受氨溴索联合头孢他啶治疗的患者作为甲组;另37例接受氨溴索联合头孢噻肟钠治疗的患者作为乙组。比较两组患者的临床效果。结果治疗后,两组患者的血清超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)和内皮素(ET)水平均降低,且甲组明显低于乙组(P<0.05)。治疗后,两组患者的FPG、2 h PG和Hb A1c水平比较,差异无统计学意义(P>0.05)。甲组并发症总发生率明显低于乙组(P<0.05)。结论对老年糖尿病合并肺炎患者给予氨溴索联合头孢他啶抗菌能够显著改善血清学各指标水平,且不影响降糖效果,还可减少并发症。

Objective To analyze the changes of serological indexes after different antimicrobial regimens treatment in elderly diabetic patients complicated with pneumonia. Methods The clinical data of 80 cases of elderly patients with diabetes complicated with pneumonia were retrospectively analyzed. Forty-three patients received ambroxol combined with ceftazidime treatment were selected as group A, and another 37 cases treated with ambroxol and cefotaxime sodium were enrolled as group B. The clinical effects of the two groups were compared. Results After treatment, the levels of serum hypersensitivity C reactive protein（hs-CRP）, interleukin-6（IL-6） and endothelin（ET） in the two groups decreased, and those in the group A were lower than the group B（P〈0.05）. After treatment, there were no significant differences in the levels of FPG, 2 hPG and HbA1c between the two groups（P〈0.05）. The total incidence of complications in the group A was lower than that in the group B（P〈0.05）. Conclusion For elderly diabetic patients complicated with pneumonia,ambroxol combined with ceftazidime treatment can significantly improve the serological indexes, and had no effect on lowering of blood glucose, with less complications.