呼出气一氧化氮测定在儿童支气管哮喘预测及诊断中的应用价值

Application value of fractional exhaled nitric oxide in the prediction and diagnosis of bronchial asthma in children

目的研究测定呼出气一氧化氮(FeNO)在儿童支气管哮喘预测及诊断中的应用价值。方法选取2014年11月至2017年3月我院的喘息患儿179例和同期非喘息儿童(正常组)40例,将喘息儿童根据哮喘预测指数(API)分为API阳性组(107例)和API阴性组(72例),比较三组的FeNO浓度、EOS%、TIgE及喘息儿童FeNO浓度与EOS%和TIgE的相关性。结果 API阳性组FeNO浓度、EOS%、TIg E均明显高于API阴性组和正常组(P<0.05);喘息儿童FeNO浓度和EOS%成正相关(r=0.223,P=0.018),与TIgE亦成正相关(r=0.586,P=0.012)。结论 FeNO浓度与IgE、嗜酸性粒细胞有着密切关系,在预测和诊断3岁以下儿童支气管哮喘应用中有一定指导意义和价值。

Objective To study the application value of fractional exhaled nitric ox ide（FeNO） in the prediction and diagnosis of bronchial asthma in children. Methods A total of 179 cases of wheezing children in our hospital from November 2014 to March 2017 and 40 cases of non-wheeze health examination children（normal group） were selected.According to the asthma prediction index（API）, wheezing children were divided into API positive group（107 cases） and API negative group（72 cases）. The FeNO concentrations, EOS%, and TIgE in the three groups were compared, and the correlation between Fe NO concentration and EOS% and TIgE in wheezing children were detected. Results Fe NO concentration, EOS%, TIgE in the API positive group were significantly higher than those in the API negative group and normal group（P〈0.05）. There was a positive correlation between FeNO concentration and EOS% in wheezing children（r=0.223, P=0.018） and a positive correlation with TIgE（r=0.586, P=0.012）. Conclusion FeNO concentration is closely related to Ig E and eosinophils. It has certain guiding significance and value in the prediction and diagnosis of bronchial asthma in children under 3 years of age.