稽留流产患者血清中IL-6、TNF-α、HIF-1α和VEGF表达

Serum levels of IL-6, TNF-α, HIF-1α and VEGF in patients with missed abortion

目的观察稽留流产患者血清中白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、低氧诱导因子-1α(HIF-1α)和血管内皮生长因子(VEGF)水平变化。方法采用ELISA检测50例稽留流产(观察组)和50例正常人工流产者(对照组)血清中IL-6、TNF-α、HIF-1α和VEGF水平。结果观察组IL-6、HIF-1α和VEGF水平明显低于对照组(P<0.05),而TNF-α水平明显高于对照组(P<0.05)。结论血清IL-6、HIF-1α、VEGF、TNF-α水平可能作为监测稽留流产的潜在标志。

Objective To observe serum levels of interleukin-6（IL-6）, tumor necrosis factor-α（TNF-α）, hypoxia inducible factor-1α（HIF-1α）, and vascular endothelial growth factor（VEGF） in patients with missed abortion（MA）. Methods Serum contents of IL-6, TNF-α, HIF-1α and VEGF in 50 MA cases（observation group） and 50 normal abortion women（control group） were determined by ELISA. Results Compared with control group, IL-6, HIF-1α and VEGF levels were decreased（P〈0.05）, while TNF-α content increased（P〈0.05） in observation group. Conclusion Serum levels of IL-6, HIF-1α, VEGF, and TNF-α might be acted as potential markers for MA patients.