microRNAs调节卵巢癌耐药分子机制的研究进展

Regulation mechanism of MicroRNAs on chemoresistance of ovarian cancer

卵巢癌是目前病死率最高的妇科恶性肿瘤,而化疗是卵巢癌术后治疗的主要手段,但其治疗效果却受限于耐药性。肿瘤耐药的产生机制复杂多样,包括药物运输蛋白的异常、细胞凋亡敏感性下降、自噬作用加强、DNA修复能力加强、药物代谢和靶点改变等。越来越多的证据表明,microRNAs通过调控多种耐药相关基因表达,在卵巢癌耐药产生中发挥重要作用。该文综述了近年来microRNAs影响卵巢癌化疗药物耐药的研究进展。

Ovarian cancer is currently the most lethal gynecological malignancy. Chemotherapy is the main therapy for ovarian cancer following surgery, but its efficacy is limited by chemoresistance. The sophisticated chemoresistant mechanisms include abnormality of drug transporters, reduction of apoptosis susceptibility, enhancement of autophagy and DNA repair capacity, and alteration of drug metabolism and targets. The increasing evidences show that microRNAs are pivotal in the chemoresistance of ovarian cancer through regulating the expression of diverse drug resistance-related genes. This paper summarized the recent advances on the effect of mi RNAs on chemoresistance of ovarian cancer.