小剂量替罗非班联合双抗血小板治疗进展性脑梗死的效果观察

Clinical efficacy of low-dose tirofiban and dual anti-platelet therapy in progressive cerebral infarction

目的观察小剂量替罗非班联合双抗血小板治疗(DAPT)进展性脑梗死的效果。方法 68例进展性脑梗死患者随机分为对照组、观察组,分别采用DAPT及小剂量替罗非班联合DAPT治疗7 d。比较两组神经功能评分、生活质量、血小板功能、疗效。结果观察组NIHSS评分、血小板黏附性和聚集率低于对照组(P<0.01),Barthel指数高于对照组(P<0.01);观察组疗效优于对照组(Hc=3.914,P<0.05)。结论小剂量替罗非班联合DAPT可提高进展性脑梗死患者的疗效和改善生活质量。

Objective To observe the clinical efficacy of low-dose tirofiban and dual anti-platelet therapy（DAPT） in progressive cerebral infarction（PCI）. Methods Sixty-eight PCI patients were randomly divided into control and observation groups, and respectively treated with DAPT and low-dose tirofiban plus DAPT for 7 days. The neurological deficit scores, quality of life, platelet function, and therapeutic efficacy were compared between 2 groups. Results Compared with control group, NIHSS scores and platelet adhesion and aggregation were lower（P〈0.01）, while Barthel index and therapeutic efficacy were higher（P〈0.01-0.05） in observation group. Conclusion Combined low-dose tirofiban with DAPT can improve the clinical efficacy and quality of life in PCI patients.