手术联合药物治疗瘢痕疙瘩的临床观察

Clinical efficacy of surgery and drug therapy in keloids

目的观察手术联合药物治疗瘢痕疙瘩的效果及安全性。方法 60例瘢痕疙瘩患者随机分为观察组和对照组,对照组给予氟尿嘧啶+曲安奈德局部注射,观察组在手术切除后局部注射。比较两组的疗效、3个月瘢痕面积及厚度,3、6个月温哥华瘢痕量表(VSS)评分和不良反应。结果观察组疗效明显优于对照组,瘢痕面积及厚度小于对照组,VSS评分和不良反应低于对照组(P<0.05)。结论手术联合药物治疗瘢痕疙瘩可提高疗效,减少不良反应。

Objective To observe the clinical efficacy and safety of surgery and drug therapy in keloid patients. Methods Sixty keloid patients were randomized to observation and control groups, and respectively treated with intralesional injection of fluorouracil and triamcinolone or keloid excision and intralesional injection. Therapeutic efficacy, 3-month scar area and thickness, 3-and 6-month Vancouver scar scale（VSS） and adverse reactions were compared between 2 groups. Results Compared with control group, therapeutic efficacy was higher, scar area and thickness were smaller, and VSS and adverse reactions were lower in observation group（P〈0.05）. Conclusion Combined usage of keloid excision and intralesional injection can improve clinical efficacy and reduce adverse reactions in keloid patients.