甘露消毒丹加减治疗儿童急性化脓性扁桃体炎临床观察

Clinical observation on the effect of modified Ganlu Xiaodu Dan in the treatment of children with acute suppurative tonsillitis

目的观察甘露消毒丹加减方辅助治疗儿童急性化脓性扁桃体炎的临床疗效。方法选取2014年3月至2017年3月郑州市第六人民医院儿科收治的急性化脓性扁桃体炎患儿108例作为研究对象,随机分为对照组和观察组各54例。对照组实施西医常规治疗,观察组在对照组治疗基础上给予中药甘露消毒丹加减方水煎剂口服。5d为1个疗程,治疗1个疗程后观察两组患儿退热时间、渗出物消失时间、扁桃体缩小时间、充血缓解时间和临床疗效、不良反应。结果观察组治愈率、总有效率分别为48.15%(26/54)、98.15%(53/54),显著高于对照组27.78%(15/54)、85.19%(46/54),差异有统计学意义(P<0.05)。观察组退热时间、渗出物消失时间、扁桃体缩小时间、充血缓解时间均显著短于对照组,差异有统计学意义(P<0.05)。两组治疗中均未见不良反应。结论甘露消毒丹加减方辅助治疗儿童急性化脓性扁桃体炎临床疗效确切,值得临床推广使用。

Objective To observe the effect of modified Ganlu Xiaodu Dan as an assistant treatment for children with acute suppurative tonsillitis. Methods A total of 108 children with acute suppurative tonsillitis were selected as the study subjects. These children were randomly divided into control group and observation group. The children in the control group were treated with conventional western medicine, while for the children in the observation group, a traditional Chinese medicine of modified Ganlu Xiaodu Dan was given besides the same treatment as the control group. The treatment lasted for 5 days as a course. After one course, the time of fever, the time of exudates disappearance, the time of tonsil contraction, the time of congestion relief and the clinical efficacy as well as adverse reactions were compared between the two groups.ResultsThe cure rate of the observation group was 48.15%（26/54）, and the total effective rate was 98.15%（53/54）, both of which were significantly higher than those of the control group[the cure rate being 27.78%（15/54）, the total effective rate being 85.19%（46/54）].The difference was statistically significant（ P 〈0.05）. The time of fever abatement, the time of exudates disappearance, the time of tonsil contraction and the time of congestion relief in the observation group were significantly shorter than those in the control group. The difference was statistically significant（ P 〈0.05）. No adverse reactions were observed in both groups.Conclusion The clinical effect of modified Ganlu Xiaodu Dan for the children with acute suppurative tonsillitis is definite, which is worthy of clinical application.