Pig-a基因突变试验研究进展

Research advances for Pig-a gene mutation assay

建立灵敏可靠的遗传毒性试验方法是全面充分评价化学物质致突变性的必要保障。近年来,一种基于Pig-a基因的新型基因突变试验成为研究热点,该方法具有灵敏度高,成本低,与其他遗传毒性试验整合潜力高,减少动物使用等优点,有望成为未来评估体内基因突变的新方法。本文就Pig-a基因突变试验的研究与应用进展进行综述。

It is important to establish sensitive and reliable method for genotoxicity tests for evaluating the potential mutagenicity of chemicals. In recent years,a new in vivo genotoxicity test based on Pig-a gene mutation has been developed and recognized to be useful for regulatory safety assessment because of its potential for clinical translation,its remarkable sensitivity to mutagenic agents,its relatively low cost,and its potential for integration with other in vivo tests as well as for reducing animal use. This paper mainly reviews the application and development of the Pig-a gene mutation assay.