丹栀逍遥散治疗广泛性焦虑症(障碍)肝郁化火型临床研究

Clinical Study on Danzhi Xiaoyao Powder in the Treatment of Generalized Anxiety(Disorder) of Pathogenic Fire Derived From Stagnation of Liver-qi Type

目的分析加减丹栀逍遥散治疗肝郁化火型广泛性焦虑症(障碍)的临床效果。方法选取2017年2月—2018年2月我院收治的80例肝郁化火型广泛性焦虑症(障碍)患者作为此次研究对象,采用随机数字表法将所有患者分为观察组(n=40)与对照组(n=40)。对照组予氟哌噻吨美利曲辛治疗,观察组给予丹栀逍遥散加减方治疗。采用汉密顿焦虑评分量表(HAMA)及焦虑自评量表(SAS)评估2组患者治疗前后的焦虑症状改善情况,并根据治疗前后的中医证候评分评估2组患者的临床疗效。结果 2组患者治疗后的HAMA及SAS评分均明显低于治疗前(P<0.05)。观察组患者治疗后的HAMA及SAS评分均明显低于对照组,差异具有统计学意义(P<0.05)。观察组患者的中医证候临床疗效明显优于对照组,差异具有统计学意义(P<0.05)。结论加减丹栀逍遥散治疗肝郁化火型广泛性焦虑症(障碍),疗效确切,可有效改善患者的焦虑症状,值得在临床大力推广和使用。

Objective To analyze the clinical effect of Danzhi Xiaoyao powder in the treatment of generalized anxiety （disorder） due to stagnation of liver qi. Methods 80 cases of generalized anxiety disorder of of pathogenic fire derived from stagnation of liver-qi type treated in our hospital from February 2017 to February 2018 were selected as the clinical research subjects, and all the patients were divided into observation （n=40） and control group （n=40） . The control group was treated with fluperthiazide medrotixin, while the observation group was given modified Danzhi Xiaoyao powder. The Hamihon Anxiety Scale （HAMA） and the self rating Anxiety Scale （SAS） were used to evaluate the improvement of the anxiety symptoms before and after the treatment of the two groups, and the clinical efficacy of the two groups was evaluated according to the TCM syndrome score before and after the treatment. Results The HAMA and SAS scores of the two groups after treatment were significantly lower than those before treatment （P 〈 0.05） . The HAMA and SAS scores of the observation group were significantly lower than those of the control group after treatment （P〈 0.05） . The clinical efficacy of TCM syndrome in the observation group was significantly higher than that in the control group, and the difference was statistically significant （P 〈 0.05） . Conclusion Modified Danzhi Xiaoyao powder is effective in the treatment of generalized anxiety （disorder） due to stagnation of liver qi, which can effectively improve the anxiety symptoms of the patients and is worthy of being popularized and used in clinical practice.