清热解郁法治疗反流性食管炎患者睡眠障碍临床研究

Clinical Study on Clearing Away Heat and Relieving Depression Therapy in the Treatment of Sleep Disorders in Patients with Reflux Esophagitis

目的观察清热解郁汤治疗反流性食管炎伴睡眠障碍的临床效果。方法纳入受试患者86例,随机分为对照组40例,观察组46例。对照组按反流性食管炎病常规治疗,观察组在对照组基础上联合应用清热解郁汤中药汤剂治疗。6周后观察患者反酸次数及程度、睡眠质量,并记录2组患者治疗有效率,评估临床疗效。结果试验组有效率为91.3%,与对照组(87.5%)比较无明显差异(P>0.05)。2组反酸次数及程度均较治疗前改善(P<0.05),观察组患者改善更加明显(P<0.05)。但对照组睡眠情况较治疗前无明显改善(P>0.05),而观察组患者睡眠情况明显改善(P<0.05)。结论清热解郁法联合兰索拉唑治疗胃食管反流伴睡眠障碍的疗效优于单用兰索拉唑治疗。

Objective To observe the clinical effect of Qingre Jieyu decoction in treating sleep disorders in patients with reflux esophagitis. Methods 86 patients were randomly divided into control group （40 cases） and observation group （46 cases） . The control group was treated with reflux esophagitis routine treatment, and the observation group was treated with Qingre Jieyu decoction combined with Chinese herbal decoction on the basis of the control group. After 6 weeks, the fi＇equency and degree of acid reflux and sleep quality were observed, the effective rate of the two groups was recorded, and the clinical effect was evaluated. Results The effective rate of the experimental group was 91.3%, which was not significantly different from that of the control group （87.5%） （P 〉0.05） . The fi＇equency and degree of acid regurgitation in the two groups were improved comparing with those before treatment （P〈 0.05） , and the improvement in the observation group was more significant （P 〈0.05） . However, there was no significant improvement in sleep condition in the control group （P〉0.05） , while sleep in the observation group was significantly improved （P〈 0.05） . Conclusion The efficacy of clearing heat and relieving depression combined with lansoprazole in the treatment of gastroesophageal reflux with sleep disorder is better than that of lansoprazole alone.