门诊精神分裂症患者代谢综合征发生率及相关危险因素的调查分析

Investigation and analysis of the incidence of metabolic syndrome and its related risk factors in outpatients with schizophrenia

目的探讨门诊精神分裂症患者代谢综合征(MS)的发生率及相关危险因素。方法选取2017年3~10月在广东省梅州市第三人民医院门诊就诊符合《国际疾病分类与诊断标准》10版(ICD-10)精神分裂症诊断标准的患者212例。采用自编的调查表[包括一般人口学资料,空腹血糖(FPG)、高密度脂蛋白(HDL-C)、收缩压(SBP)等]进行调查分析。结果实际共收集资料197例,应答率为92.3%。25.4%(50/197)的门诊精神分裂症患者存在MS,以是否存在MS为因变量,人口学基本资料和临床学资料为自变量,在进入水准α=0.05,剔除水准β=0.10下,进行二分类Logistic回归分析。Logistic结果显示,FBG和SBP越高,MS患病率越高;而文化程度和HDL-C越高,MS患病率越低。结论约1/4门诊精神分裂症患者存在代谢综合征。另外,FPG、SBP、低学历和低HDL-C是门诊精神分裂症患者出现MS,进而诱发心血管疾病的危险因素。

Objective To explore the incidence and risk factors of metabolic syndrome（MS） in outpatients with schizophrenia. Methods There were 212 cases of schizophrenia diagnosed in the Third People′s Hospital of Meizhou City from March to October 2017 were selected, and 212 patients with schizophrenia were diagnosed according to ICD-10. Results There were 197 patients were collected, the response rate was 92.3 %, and 25.4%（50/197） patients had MS. Under the condition of entering level α=0.05 and excluding level β=0.10, two classification Logistic regression analysis was carried out. MS was set as dependent variable, demographic basic data and clinical data were set as independent variables. The results of Logistic regression showed that the higher level the FBG and SBP get, the higher prevalence MS had, while the higher the education level and HDL-C, the lower the prevalence of MS. Conclusion About 1/4 of outpa tients with schizophrenia have MS. In addition, high FBG, high SBP, low educational background and low（HDL-C） may be the causes of MS in outpatients with schizophrenia. Furthermore, MS is the risk fator for, cardiovascular disease.