预防性抗癫痫药物治疗脑肿瘤相关性癫痫的效果评价

Evaluation of Antiepileptic Drugs in Patients with Epilepsy Caused by Brain Tumor

目的评价预防性抗癫痫药物治疗脑肿瘤相关性癫痫的意义。方法对确诊治疗的脑肿瘤患者病例资料进行整理,根据用药情况分为观察组和对照组,对比分析2组患者的治疗效果。结果治疗后3个月,观察组患者癫痫发生率为12.0%,显著低于对照组(26.0%);组间差异具统计学意义(P<0.05);治疗后12个月,观察组患者癫痫发生率为22.0%,对照组患者癫痫发生率28.0%;组间差异不具统计学意义(P>0.05)。治疗后3个月2组患者癫痫发作频率差异无统计学意义(P>0.05);治疗后12个月,观察组患者发作≥3次发生率36.4%,显著低于对照组(64.3%),组间差异具统计学意义(P<0.05)。治疗后2组患者不良反应发生率差异无统计学意义(P>0.05)。结论预防性抗癫痫药物治疗脑肿瘤相关性癫痫可提高患者远期生活质量,收益肯定。

Objective To study the Clinical significance of antiepileptic drugs in patients with brain tumors. Methods A total of 2 kinds of patients with brain tumors were collected and divided into the observation group and the control group. Results 3 months after treatment,the incidence of epilepsy in the observation group was 12. 0%,significantly lower than that of the control group（ 26. 0%）,the difference between the 2 groups was statistically significant（ P〈0. 05）; After 12 months of treatment,the incidence of epilepsy in the observation group was 22. 0%,higher than that of the control group（ 28. 0%）,the difference between the 2 groups was not statistically significant（ P〉0. 05）. 3 months after the treatment 2 groups of patients with seizure frequency difference was not statistically significant（ P〉0. 05）; 12 months after treatment,the patients in the observation group more than 3 times attack occurred were 36. 4%,significantly lower than the control group（ 64. 3%）,with statistically significant difference between the 2 groups（ P〈0. 05）. After treatment,the incidence of adverse reactions between the 2 groups was not statistically significant（ P〉0. 05）. Conclusion Antiepileptic drug therapy in patients with brain tumors can improve the quality of life of patients,and make sure that the quality of life.