影响保乳术治疗乳腺癌术后复发的相关因素分析

Analysis of Related Factors of Postoperative Recurrence of Breast Cancer Treated by Breast Conserving Surgery

目的分析乳腺癌采用保乳术治疗后复发的相关因素。方法选取行保乳术治疗的乳腺癌患者120例。建立数据库,统计术后1、2、3、4年复发情况,统计复发率;对比不同年龄、不同肿瘤直径、不同淋巴结转移情况、不同Ki-67表达、不同乳腺癌TNM分期、不同病理类型和分子分型患者复发率;采用多因素分析找出复发危险因素。结果复发率为12.50%。单因素分析发现,年龄≤40岁的患者中复发率较年龄>40岁的患者高;有淋巴结转移患者复发率较无淋巴结转移患者高;KI-67阳性者复发率明显高于阴性者;Her-2阳性型术后复发率较其它分子分型高(P<0.05)。多因素分析发现年龄、分子分型、淋巴结转移为复发独立危险因素(P<0.05)。结论分子分型、淋巴结转移情况、患者年龄均对乳腺癌保乳术术后复发有影响。

Objective To analyze the related factors of recurrence after breast conserving surgery. Methods 120 patients with breast cancer who underwent breast conserving surgery were selected. Establishment of a database,1-,2-,3-,4-year recurrence,and recurrence rates were collected. To compared with the different age,different tumor diameter,different lymph node metastasis,different Ki-67 expression,different breast cancer TNM stage,different pathological types and molecular type of recurrence rate,multivariate analysis was used to identify risk factors for recurrence. Results The recurrence rate was 12. 50%. Univariate analysis found that patients≤ 40 years were more likely to have a higher recurrence rate than those patients〉 40 years; patients with lymph node metastases were higher than those without lymph node metastasis; the recurrence rate of KI-67 positive expression was significantly higher than that of negative expression; The molecular recurrence rate of Her-2 positive type was higher than other molecular typing（ P〈0. 05）. Multivariate analysis showed that age,molecular typing and lymph node metastasis were independent risk factors for relapse（ P〈0. 05）. Conclusion Molecular classification,lymph node metastasis and age of patients have an effect on recurrence of breast cancer after breast conserving surgery.