Ⅰ_A期乳腺癌妇女的临床病理特征与生存状况研究

Clinicopathological Characteristics and Survival of Women with Stage Ⅰ_A Breast Cancer

目的研究Ⅰ_A期乳腺癌妇女的临床病理特征与生存状况。方法回顾性分析138例Ⅰ_A期乳腺癌患者临床资料,采用统计学分析方法对所有患者临床资料进行统计分析。结果术后对所有患者进行中位随访,5年PFS为94.2%,5年OS为98.9%。138例患者中12例发生复发或转移。T1b期复发或转移3例,T1c期复发或转移9例。138例患者生存状况单因素分析结果显示:Ki-67表达、不同的手术方式、放疗手段和组织学分级与患者PFS相关(P<0.05),患者年龄、临床分期及曲妥珠单抗的使用与否对PFS无明显影响。Ki-67表达和组织学分级是影响患者PFS独立预后因素(P<0.05),且组织学分级中低级患者的PFS优于组织学分级高级患者,Ki-67表达<14%优于Ki-67表达≥14%者。结论Ⅰ_A期乳腺癌患者总的术后生存状况较好,对于某些亚组患者存在一定的复发率和转移率,且风险较大。

Objective To study the clinicopathological features and survival of women with stage ⅠAbreast cancer.Methods The clinical data of 138 patients with stage ⅠAbreast cancer were retrospectively analyzed. The clinical data of all patients were analyzed by statistical analysis. Results All patients were followed up,5-year PFS was 94. 2% and 5-year OS was98. 9%. 138 patients had recurrence or metastasis in 12 cases. T1 brecurrence or metastasis occurred in 3 cases,T1 crecurrence or metastasis in 9 cases. Single factor survival analysis showed that Ki-67 expression and different surgical procedures,radiotherapy and the histological grading were related with PFS（ P〈0. 05）,age,clinical stage and trastuzumab has no evident effect on PFS.The expression of Ki-67 and grade were independent prognostic groups factors for PFS（ P〈0. 05）,and patients with lower histological grade had higher PFS than patients with higher histological grade,the expression of Ki-67 〈14% is better than Ki-67 expression more than 14% people. Conclusion The overall survival rate of patients with stage ⅠAbreast cancer is good,and there is a certain recurrence rate and metastasis rate in some subgroups,and the risk is higher.