青海省海晏县鼠疫菌病原分析及流行病学意义

Etiology study and epidemiological significance of Yersinia pestis in Haiyan County of Qinghai Province

对1960-2017年间青海省海北藏族自治州海晏县分离的17株鼠疫菌株进行生化试验、毒力测定、毒力因子鉴定、质粒分析、鼠疫菌差异区段DFR(Different Region)分型等研究,分析探讨青海省海晏县鼠疫菌株生物学特点及流行病学意义,为该地区的鼠疫防控策略提供科学依据。结果表明:青海省海晏县分离的鼠疫菌具备青藏高原鼠疫病原体特性,鼠疫菌的毒力强,因此要加大该地区的鼠疫监测、防控、宣传力度,严防动物间鼠疫波及人间。

The biochemical test,toxicity test,virulence factors evaluation,plasmid analysis and Different Region（ DFR） genotyping were implemented for total 19 strains of Yersinia pestis separated from different kinds of host in Haiyan County,Qinghai province from 1956 to 2017,and investigate the biological characteristics and epidemiological significance of Yersinia pestis strains in Haiyan County,Qinghai Province,and aims at providing a scientific basis for plague prevention and control. The results showed that the strains separated in Haiyan county,Qinghai Province had the characteristics of Qinghai-Tibet plateau plague ＇s pathogen,and had strong toxicity. So we should enhance the plague monitoring and give more publicity to plague prevention to prevent animal plague spreading to human.