幽门螺旋杆菌感染与中老年血肌酐水平相关研究

Helicobacter pylori infection is closely associated with plasma creatinine concentration

目的探讨幽门螺旋杆菌(HP)感染与血肌酐水平的关系。方法选取2013年12月~2016年6月解放军海军总医院住院患者174例,分为53例HP感染者和121例正常对照者,对比观察两组年龄、性别、总胆固醇(TC)、三酰甘油(TG)、空腹血糖(FBG)、肌酐(CRE)和尿素氮(BUN)水平。结果两组间血肌酐和尿素氮比较差异有统计学意义(P<0.05)。多因素binary logistic regression分析发现肌酐是HP感染的相关因子(P<0.05)。结论 HP感染者血肌酐和尿素氮水平升高,HP感染可能参与慢性肾功能不全的发生。

Objective This study investigated the relationship between helicobacter pylori infection and plasma creatinine concentration. Methods We observed age, helicobacter pylori infection, total plasma cholesterol, plasma triglyceride, fasting glucose and plasma creatinine concentration. Method The study selected 53 helicobacter pylori infection and 121 no helicobacter pylori infection patients who were consecutively referred by general practitioners for routine medical check-up or medical treatment. Results Plasma creatinine and blood urea nitrogen concentration were significant different between helicobacter pylori infection and control group（P 0.05）. Helicobacter pylori infection was taken as a dependent variable and age, sex, total cholesterol, triglyceride, fasting glucose, plasma creatinine concentration and blood urea nitrogen were taken as independent variables, we found that plasma creatinine concentration（β =1.06,P 0.05） was significantly associated with the risk for helicobacter pylori infection analyzed by binary logistic regression. Conclusion Patients with helicobacter pylori infection were more likely to have high plasma creatinine concentration level, and helicobacter pylori infection may take part in chronic renal insufficiency.