周细胞作为胶质瘤潜在治疗靶点研究进展

Researches on Pericytes as Potential Therapeutic Targets for Glioma

胶质瘤是成人颅内最常见的恶性肿瘤,其恶性度高,预后差,且目前无有效治疗方案。近年来随着对胶质瘤微环境分子生物学研究不断深入,研究者相继发现了多个潜在治疗靶点,然而在临床实践中并未取得满意疗效。近期相关研究发现周细胞在胶质瘤的发生发展中起到重要作用,有望作为治疗胶质母细胞瘤的潜在靶点。本文将对周细胞在胶质瘤中的最新研究进展进行综述,为其进一步的科研提供依据。

Glioma is the most commonly seen malignant tumor in adults,characterized by high malignancy,frequent recurrence and poor prognosis. There is currently no effective therapy for this disease. In recent years,as researches on molecular biology in glioma microenvironment increasingly deepens,researchers have discovered a number of potential therapeutic targets. However,satisfactory results have not been achieved in clinical practice since then. Recent studies have found that pericytes play an important role in the development of gliomas,and can be used as a potential therapy for glioblastoma. This article will review the latest researches on pericytes,and provide evidences for further researches.