肝硬化门脉高压顽固性腹水病人TIPSS术前后血管紧张素Ⅱ水平的变化

Angiotensin Ⅱ(AT Ⅱ) level fluctuationin on cirrhotic portal hypertension patients with chronic ascites pre and post TIPSS

目的 监测和分析肝硬化门脉高压顽固性腹水患者 TIPSS术前后血中血管紧张素 (AT- )的变化。 材料与方法 采用放射免疫分析法对行 TIPSS术的 5 6例患者术前、术中及术后与 33例原发性肝癌行肝动脉栓塞 (TAE)治疗前后的空腹外周静脉、门静脉及肝固有动脉血中 AT- 水平进行了比较。 结果 TIPSS术前的门静脉 AT- 水平为最高 ,依次高于肝静脉、外周静脉、对照组的外周静脉及肝固有动脉 ,P<0 .0 1。 结论 肝硬化门脉高压顽固性腹水患者 TIPSS术前 AT- 水平较高 ,尤其 TIPSS术中肝内门静脉穿刺所取血样 AT- 水平最高 ;而术后的 AT- 水平则明显降低。这可能是肝硬化门脉高压顽固性腹水患者行 TIPSS术后腹水消失的原因之一。

Purpose To observe and analysis the transformation of angiotensin Ⅱ(AT Ⅱ) in cirrhotic patients with chronic ascites pre and post TIPSS. Materials Fifty six angiotensin Ⅱ were immunoradiology analysis in patients with TIPSS procedure. Compare to peripheral vein, portal vein and hepatic artery of 33 patients with hepatocellular carcinoma (HCC) fore and aft underwent transcatheter arterial embolization(TAE). Results The AT Ⅱ level of portal vein before TIPSS is tiptop and hepatic vein 〉peripheral vein 〉hepatic artery in succession. P <0.01. Conclusion AT Ⅱ level of Cirrhotic patients with chronic ascites were depressed in evidence after TIPSS placement, may be one of cause of cirrhotic patients with chronic ascites reduce possibly.