摘要
The past two decades have witnessed a revolution in identifying genetic risk factors underlying diseases and complex traits using genome-wide association studies （GWAS） （Risch and Merikangas, 1996; Hirschhom and Daly, 2005; Altshuler et al., 2008）. Together with advanced high-throughput technologies for genotyping and sequencing, GWAS have discovered thousands of susceptibility loci for various traits （Welter et al., 2014）.
The past two decades have witnessed a revolution in identifying genetic risk factors underlying diseases and complex traits using genome-wide association studies （GWAS） （Risch and Merikangas, 1996; Hirschhom and Daly, 2005; Altshuler et al., 2008）. Together with advanced high-throughput technologies for genotyping and sequencing, GWAS have discovered thousands of susceptibility loci for various traits （Welter et al., 2014）.
基金
supported by the Fundamental Research Funds for the Central Universities (BLX2013026)
the National Natural Science Foundation of China (No. 31470675)
the National Institutes of Health (K01AA023321)
supported by the National Heart, Lung, and Blood Institute in collaboration with Boston University (Contract No. N01-HC-25195)
Funding for SHARe Affymetrix genotyping was provided by NHLBI Contract N02-HL-64278
