Fibroscan定量评价非酒精性脂肪肝合并HBV感染临床研究

Clinical study on quantitatively evaluating fatty liver with HBV infection by fibroscan

目的研究乙型肝炎病毒(HBV)病毒载量、肝脏硬度值(LSM)等对受控衰减参数(CAP)的影响。方法收录我院2015年1月~2017年4月诊断为HBV感染合并非酒精性脂肪肝患者443例。统计项目包括瞬时弹性成像技术(Fibroscan)检查结果 CAP和LSM、性别、年龄、谷丙转氨酶(ALT)、谷丙转氨酶(AST)、乙型肝炎病毒载量(HBV-DNA)等。所有数据应用SPSS17.0软件进行分析。结果 LSM,ALT,AST,HBV-DNA与CAP进行线性回归分析,LSM对CAP有显著影响(P<0.05),肝脏炎症程度ALT,AST及HBV-DNA高低对CAP无显著影响(P均>0.05)。结论转氨酶(ALT,AST),HBV-DNA对CAP测量无显著影响,LSM对CAP指标有显著影响。

Objective To study the influence of HBV viral load and liver hardness value（ LSM） on controlled attenuation parameters（ CAP）. Methods Four hundred and forty-three cases of HBV infection and non-alcoholic fatty liver disease diagnosed in our hospital from January 2015 to April 2017 were included. Statistical items： Transient Elastic Imaging technique： CAP and LSM,gender,age,alanine transaminase（ ALT）,glutamate transaminase（ AST）,hbv-dna（ HDA）,etc. All datas were analyzed by SPSS17. 0 software. Results LSM,ALT,AST,hbv-dna and CAP were linear regression analysis. LSM had a significant effect on CAP（ P〈0. 05）,and there was no significant effect of ALT,AST and hbv-dna on the level of liver inflammation（ P = 0. 72,0. 54,0. 10〉0. 05）. Conclusion Aminotransferase（ ALT,AST） and HBV-DNA had no significant effect on CAP measurement. LSM has significant influence on CAP index.