慢性阻塞性肺疾病急性加重患者血清ST2,CRP,DD水平变化及意义

Changes and significance of serum ST2,CRP,D-dimer in acute exacerbation chronic obstructive pulmonary disease

目的探讨慢性阻塞性肺疾病急性加重(AECOPD)患者血清人基质裂解素2(ST2)、C反应蛋白(CRP)、D-二聚体(DD)的水平变化及临床意义。方法选取2016年4月~2017年3月住院的AECOPD患者60例(观察组),同时选取健康对照组30例(对照组),观察AECOPD患者治疗前、后血清ST2,CRP,DD的水平变化。结果 (1)治疗前观察组患者血清ST2,CRP,DD水平较对照组均明显升高,差异均有统计学意义(P<0.05)。(2)治疗后观察组血清ST2,CRP,DD均较治疗前显著降低,差异均有统计学意义(P<0.05)。结论经有效治疗后AECOPD患者血清ST2,CRP,DD水平均降低,联合检测多种炎性因子可作为AECOPD患者病情变化的依据。

Objective To explore the expression level and clinical significance of serum ST2,CRP,D-dimer in patients with acute exacerbation chronic obstructive pulmonary disease（ AECOPD）. Methods From April 2016 to March 2017,60 cases of AECOPD patients at hospital were selected. Thirty cases of healthy control group were also selected. The changes of serum ST2,CRP,DD and correlation data analysis were observed before and after treatment. Results（1）Before treatment,the serum levels of ST2 CP-DD in the observation group were significantly higher than those in the control group,differences were statistically significant（ P〈0. 05）.（2）After treatment,the serum levels of ST2 and CRP DD in the observation group were significantly lower than those before treatment,the differences were statistically significant（ P〈0. 05）. Conclusion After effective treatment,serum levels of ST2 and CRP DD decreased in patients with AECOPD. The combination of various inflammatory can be used as a basis for the change of AECOPD patients.