术前体质指数对绝经前后乳腺癌患者预后的影响

Effect of preoperative body mass index on prognosis of postmenopausal breast cancer patients

目的探讨绝经前后体质指数(BMI)与乳腺癌复发风险及生存期的关系。方法回顾性分析2005年1月~2011年2月间接受手术治疗的乳腺癌患者2859例,分别对绝经前和绝经后组进行生存分析。结果淋巴结转移数目、雌激素受体(ER)、孕激素受体(PR)和术前BMI均是绝经前乳腺癌患者无病生存期(DFS)和总生存期(OS)的影响因素,BMI对绝经前乳腺癌患者的DFS影响差别不明显,BMI高者对OS预后较好(P<0.05);淋巴结转移数目、PR和术前BMI均是绝经后患者DFS和OS的影响因素;BMI低者绝经后患者DFS和OS明显好于其他组(P<0.05)。结论肥胖对绝经前乳腺癌患者复发影响不大,偏瘦者对绝经后乳腺癌患者预后较好。

Objective To explore the relationship between the body mass index（BMI） and breast cancer recurrence risk and survival. Methods The date of 2859 patients after surgery in premenopausal group and postmenopausal group were analyzed. Results The number of lymph node metastasis,ER,PR and preoperative BMI were the influence factors of premenopausal breast cancer with disease free survival（DFS） and overall survival（OS）（P〈 0. 05）; The number of lymph node metastasis,PR and preoperative BMI were the factors influencing the DFS and OS in postmenopausal patients,and the DFS and OS of postmenopausal patients with low BMI were significantly better than those in other groups（P 〈0. 05）. Conclusion Obesity has little effect on the recurrence of premenopausal breast cancer patients,and under weight is good for postmenopausal breast cancer patients.