B7-H3在结肠癌组织中的表达及其临床病理意义

Expression of B7-H3 protein in colon carcinoma and clinical pathological significance

目的 研究B7-H3在结肠癌组织中的表达及其临床病理意义.方法 收集2009年1月至2017年4月商丘市第一人民医院病理科存档的蜡块标本72例.采用免疫组织化学SP法检测B7-H3在72例结肠癌患者癌组织中的表达水平,分析B7-H3表达与年龄、性别、组织学分化程度、TNM分期和淋巴结转移等临床参数的相关性.结果 B7-H3在结肠癌组织中阳性表达率为75.0％（54/72）;B7-H3的阳性表达与结肠癌患者的性别、年龄、组织学分化无关（P〉0.05）,而与肿瘤分期和有无淋巴结转移相关（P〈0.05）.结论 B7-H3在结肠癌组织中的表达上调,且与肿瘤分期、淋巴结转移密切相关,可作为结肠癌治疗的潜在靶点之一.

Objective To investigate the expression of B7-H3 in colon carcinoma and analyze its clinical pathological significance. Methods Seventy-two paraffin specimens stored in Department of Pathology in the First People＇s Hospital of Shangqiu from January 2009 to April 2017 were collected. The expression of B7-H3 in 72 patients with colon carcinomas were detected by immunohistochemistry. The correlation between BT-H3 expression and clinicopathologic features （age, gender, histologic differentiation, TNM stage, lymph node metastasis ） were analyzed. Results The positive expression rate of B7-H3 in colon carcinomas was 75.0% （54/72）. The expression of BT-H3 in patients with colon carcinomas was closely correlated with tumor stage and lymph node metastasis （P 〈 0. 05） , but it was irrelevant to gender, age and tumor differentiation （P 〉 0. 05 ）. Conclusions The over expression of B7-H3 in colon carcinoma is correlated with tumor stage and lymph node metastasis and it might be a new potential target of therapy.