碳酸锂治疗双相情感障碍抑郁发作对患者甲状腺功能的影响

Influence of lithium carbonate on thyroid function in patients with bipolar affective disorder

目的 分析碳酸锂治疗双相情感障碍抑郁发作对患者甲状腺功能的影响.方法 选取深圳市康宁医院2016年4月至2017年11月收治的30例双相情感障碍抑郁发作患者作为观察组,另选取同期30例健康体检者作为对照组,比较两组甲状腺功能.结果 观察组用药前甲状腺素（T4）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）均明显低于对照组（P均〈0.05）;而两组治疗前三碘甲状腺原氨酸（T3）和促甲状腺激素（TSH）浓度比较差异未见统计学意义（P〉0.05）.观察组使用碳酸锂后FT4较用药前明显降低（P〈0.05）.结论 碳酸锂治疗双相情感障碍抑郁发作能够在一定程度上降低患者的甲状腺功能.

Objective To analyze effects of lithium carbonate on thyroid function in patients with bipolar affective disorder. Methods Thirty patients with bipolar disorder and depressive episode treated in Shenzhen Kangning hospital from April 2016 to November 2017 were selected as observation group.Another 30 healthy persons in the same period were selected as control group, and the thyroid function of the two groups was compared. Results The thyroxine 4 （T4） , free thyroxine 3 （ FT3 ） and free thyroxine 4 （FT4） in observation group were significantly lower than those in control group before treatment （ P 〈 0. 05 ）. There was no significant difference in serum thyroxine 3 （ T3 ） and thyroid stimulating hormone （TSH） concentration between the two groups before treatment （ P 〉 0. 05 ）. In observation group, FT4 was significantly decreased after using lithium carbonate （P 〈 0. 05 ）. Conclusions Lithium carbonate in the treatment of bipolar affective disorder can reduce the patients＇ thyroid function in a certain degree.