摘要
以廉价易得的丙酮肟为原料,通过氘化铝锂还原,与氯化氢二氧六环溶液成盐得到目标化合物(2-氘)丙-2-胺盐酸盐。其结构经~1 HNMR和ESI-MS确证。最佳反应条件为:n(丙酮肟)∶n(氘化铝锂)=2∶1,反应溶剂为四氢呋喃,在70℃下反应3h,产品收率为52%。
（2-Deuterium）propan-2-amine hydrogen chloride was synthesized from 2-propanone oxime through 2 steps,involving reduction by lithium tetradeuteridoaluminate,salt-forming reaction in the presence of hydorgen chloride in 1,4-dioxane.The structure of the product was confirmed by 1 HNMR and ESI-MS.The optimal reaction conditions were investigated.The results showed that the target product,（2-deuterium）propan-2-amine hydrogen chloride,was obtained in a yield of 52% with n（2-propanone oxime）∶n（lithium tetradeuteridoaluminate） 2∶1 at 70℃ for 3 hin tetrahydofuran as solvent.
作者
仝红娟
杜漠
赵敏
徐玉美
张彦民
刘斌
TONG Hong-juan;DUMo;ZHAOMin;XUYu-mei;ZHANG Yan-min;LIUBin(School of Pharmacy,Shaanxi Institute of International Trade＆Commerce,Xi＇an 712046,China;Collaborative Innovation Center of Green Manufacturing Technology for Traditional Chinese Medicine in Shaanxi Province,Xi＇an 712046,China)
出处
《精细与专用化学品》
CAS
2018年第8期34-36,共3页
Fine and Specialty Chemicals
基金
陕西省大学生创新创业项目(201849002)
陕西国际商贸学院校级项目(SMXY201805)
关键词
(2-氘)丙-2-胺盐酸盐
氘化铝锂
还原反应
合成
（2-deuterium）propan-2 amine hydrogen chloride
lithium tetradeuteridoaluminate
reduction reaction
synthesis
