七氟醚预处理对颅内动脉瘤夹闭术中血清丙二醛和超氧化物歧化酶的影响

Effect of sevoflurane preconditioning on concentration of jugular MDA and SOD in patients undergoing intracranial aneurysm clipping

目的评价七氟醚预处理对颅内动脉瘤夹闭术血清中MDA和SOD浓度的影响。方法择期行颅内脑动脉瘤夹闭术患者40例,美国麻醉医师协会(ASA)分级Ⅱ或Ⅲ级,年龄40-65岁。随机分为七氟醚组(S组,n=20)和对照组组(C组,n=20),其中S组麻醉诱导后给予2%七氟醚预处理,30min后洗出,C组不作处理。采用比色法测定麻醉前(T0)、上临时动脉夹前即刻(T_1)、上临时动脉夹30min(T_2)、动脉瘤夹闭夹闭2h(T_3)、4h(T_4)5个时间点血中MDA、SOD浓度。结果与T_0相比,两组患者在T_2、T_3和T_4时点血清MDA显著升高、SOD水平显著降低(P<0.05);S组患者血清中MDA水平在T_2、T_3和T_4时间点明显低于C组(P<0.05);与C组相比,S组患者血清中SOD水平在T_2、T_3和T_4时间点明显增高(P<0.05)。结论七氟醚预处理颅内动脉瘤夹闭术患者可降低MDA含量,增加血清SOD活性,具有一定神经保护作用。

Objective To study the effect of sevoflurane preconditioning on concentration of jugularMalondialdehyde（MDA）andSuperoxide Dismutase（SOD）in patients undergoing intracranial aneurysm clipping.Methods 40 patients receiving intracranial aneurysm clipping were randomly divided into tow groups：control group（C group,n=20）andsevoflurane group（Sgroup,n=20）.The patients in sevoflurane group were given sevoflurane inhalation preconditioningfor 30 min after tracheal intubation,while the control group didn＇t be given inhalation anesthesia measures.The intraoperative conditions of patients in the twogroups were observed,and Malondialdehyde（MDA）andSuperoxide Dismutase（SOD）in before induction（T0）,immediately before temporary arterial occlusion（T1）,30 min（T2）of temporary arterial occlusion,and 2 h（T3）,4 h（T4）after cerebral aneurysm clipping.Results The MDA concentration was significantly higher,and SOD concentration lower at T2-T4 in bothgroupsthan that atT0 and T1（P〈0.05）;compared with the C group,the concentrationof MDA in group S was lower at T2-T4（P〈0.05）,while the SOD levels in S group were significantly higher than that of group C（P〈0.05）.Conclusion Sevoflurane mayinhibit the release of MDA andprotectthe brain inpatients undergoingintracranial aneurysm clipping.