助阳通痹颗粒治疗脾肾阳虚、肺络痹阻型间质性肺疾病

Zhuyang Tongbi granule in treating interstitial lung disease of spleen kidney yang deficiency and lung collateral obstruction

目的观察助阳通痹颗粒治疗间质性肺疾病(脾肾阳虚,肺络痹阻)的临床疗效及其抗肺纤维化的作用机理。方法将符合纳入标准的72例间质性肺疾病患者病例随机分为治疗组与对照组,各36例。治疗组予助阳通痹颗粒,对照组予强的松及N-乙酰半胱氨酸口服,观察2组患者临床症状及肺通气情况。结果治疗组患者的咳嗽、喘促气短等症状缓解情况明显优于对照组(P<0.05),治疗组临床总有效率为75.0%,优于对照组的63.9%,有统计学意义(P<0.05)。结论助阳通痹颗粒治疗间质性肺疾病(脾肾阳虚,肺络痹阻)可有效缓解患者的咳嗽、喘促气短等症状,改善PO_2,增加机体免疫力,阻止或延缓肺纤维化的进展。

Objective To investigate the efficacy of Zhuyang Tongbi granule in the treatment of interstitial lung disease of spleen kidney yang deficiency and lung collateral obstruction, and its mechanism of anti-pulmonary fibrosis. Methods 72 patients with interstitial pulmonary disease were randomly divided into treatment group and control group with 36 cases each. The treatment group was treated with Zhuyang Tongbi granule, while the control group was treated with prednisone and N-acetylcysteine. The clinical symptoms and pulmonary ventilation were observed in the 2 groups. Results The relief of cough and shortness of breath in the treatment group was significantly better than that in the control group（P〈0.05）. The total effective rate of the treatment group was 70.5% and 63.9% of the control group, The comparison between the two groups has statistical significance（P〈0.05）. Conclusion The treatment of interstitial lung diseases（deficiency of spleen and kidney yang, obstruction of lung collaterals and arthralgia） with Zhuyang Tongbi granule can effectively relieve the symptoms of cough, shortness of breath and asthma, improve PO2, increase immunity and prevent or delay the progress of pulmonary fibrosis.