212831例不同人群乙肝五项标志物结果分析

Analysis of five hepatitis B virus markers in 212,831 cases from different populations

目的探讨郑州地区不同人群乙肝五项标志物模式的分布及特点。方法采用ELISA法对血样进行HBV血清学指标检测,收集2012年9月28日至2017年9月27日在我院检查的乙肝五项定性检测结果,进行不同模式分析。结果 212 831例检测者中HBsAg阳性者有6 103例,其中男性3 177例,女性2 926例,男女HBsAg阳性率比较,差异有统计学意义(χ~2=43.26,P<0.01)。乙肝主要模式"1,3,5阳"、"1,4,5阳"和"1,5阳"分别占17.88%、56.81%和23.12%,"1,5阳"模式按性别比较,差异有统计学意义(χ~2=7.31,P<0.01),其他乙肝模式按性别比较,差异无统计学意义(χ~2=0,3.43,0.35和1.91,Ps>0.05);不同年龄组HBsAg阳性率比较,差异有统计学意义(χ~2=1 396.48,P<0.01)。受检人群中抗-HBs阳性有79 222例(占37.22%),不同年龄组和不同性别人群抗-HBs比较,差异有统计学意义(χ~2=1 220.18,353.03,Ps<0.01);受检人群中乙肝全阴模式91 819例(占43.14%)。结论郑州地区男性HBsAg阳性率略高于女性,而女性抗-HBs阳性率略高于男性。郑州乙肝全阴模式比例较高,提示主动免疫工作有待加强。

Objective To explore the distribution and characteristics of five markers of hepatitis B virus（HBV）in different populations in Zhengzhou.Methods ELISA was used to detect the serological markers of HBV.The qualitative results of the five HBV markers in our hospital during September 28,2012 to September 27,2017 were analyzed using different models.Results Among the total 212,831 cases,there were6,103 HBsAg positive cases,including 3,177 males and 2,926 females.The difference in the positive ratios of HBsAg between male and female was statistically different（χ^2=43.26,P〈0.01）.The main patterns of Hepatitis B were ＂ 1,3,5＂ positive, ＂ 1,4,5 positive＂ and ＂ 1,5 positive＂,accounting for 17.88%,56.81% and 23.12% respectively.Statistically significant difference was seen in ＂1,5 positive＂ pattern between male and female（χ^2=7.31,P〈0.01）but not in the other patterns（χ^2=0,3.43,0.35 and1.91,Ps0.05）.The positive ratios of HBsAg were significantly different between different age groups（χ^2=1 396.48,P〈0.01）.79,222 cases（37.22%）were anti-HBs positive.The anti-HBs positive rates were significantly different among different age and gender groups（χ^2=1 220.18,353.03,Ps0.01）.91,819 cases（43.14%）were negative for all the five markers.Conclusion The positive rate of HBsAg in male in Zhengzhou was slightly higher than in female,while the positive rate of anti-HBs in female was slightly higher than in male.The negative rates for all five markers of hepatitis B in Zhengzhou was higher,indicating that the active immunization measures need to be strengthened.