小脑肿瘤患者高级认知功能及情感障碍相关因素分析

Factors related to advanced cognitive function and affective disorder in patients with cerebellar tumor

目的 通过对影响小脑肿瘤患者认知功能以及情感障碍的相关因素进行分析,为今后针对小脑病变的诊治、康复和预后提供相关依据.方法 2016年1月—2017年6月采用便利抽样方法,选取北京天坛医院收治的小脑肿瘤患者44例,分别在其术前和术后6个月时,采用简易精神状态量表（MMSE）、汉密顿焦虑量表（HAMA）、汉密顿抑郁量表（HAMD）及临床记忆量表,对患者认知功能障碍、情感障碍情况进行评估,对影响患者认知功能和情感功能的相关因素进行分析.结果 44例小脑肿瘤患者,术前MMSE量表（21.15±4.82）分、临床记忆量表（97.74±6.84）分、HAMA量表（22.48±3.21）分、HAMD量表（21.57±2.85）分,术后6个月评估时分别为（23.86±3.96）、（113.37±10.54）、（15.48±3.13）、（14.84±2.16）分,差异均有统计学意义（P〈0.01）.术后6个月,病程、病情危重程度、肿瘤水肿程度不同的患者其高级认知功能以及情感功能得分差异有统计学意义（P〈0.05）.结论 小脑肿瘤患者大多存在着不同程度的认知功能障碍,如记忆功能、执行功能或者语言功能等方面的损伤,同时受到病情影响,情感功能方面也存在着一定障碍,从而间接对患者的生活质量造成了不良影响.

Objective To analyze the related factors of cognitive function and affective disorder in patients with cerebellar tumor, and to provide the basis for the diagnosis, treatment, rehabilitation and prognosis of cerebellar disease in the future. Methods A total of 44 patients with cerebellar tumor were selected from January 2016 to June 2017 in Beijiug Tian Tan Hospital. Mini Mental State Scale （MMSE）, Hamilton Anxiety Scale （HAMA）, Hamihon Depression Scale （HAMD） and Memory Quotient （MQ） were used to evaluate patients＇ cognitive dysfunction and affective disorders before operation and at 6 months after operation. Related factors of cognitive function and affective disorder were analyzed. Results Before operation, patients＇ MMSE was （21.15 ± 4.82） points; MQ was （97.74 ± 6.84） points, HAMA was （22.48 ± 3.21） points and HAMD was （21.57 ± 2.85） points. After 6 months, they were （23.86 ± 3.96）, （113.37 ± 10.54）, （15.48 ± 3.13） and （14.84 ± 2.16） respectively. The differences were statistically significant （P 〈 0.01）. At 6 months after operation, patients with different course of disease, severity of illness, tumor edema had different advanced cognitive function and affective function （P 〈 0.05）. Conclusions Patients with cerebellar tumor have cognitive function disorder of different level mostly, such as memory, executive function or language function. And their affective function may also has some disorder as patients were influenced by disease which will affect patients＇ quality of life indirectly.