盐酸米诺环素软膏联合甲硝唑凝胶局部应用对预防种植牙术后感染的临床疗效

Clinical efficacy of minocycline hydrochloride combined with metronidazole gel topical medication for prevention of postoperative infections of dental implants

目的探讨局部应用盐酸米诺环素软膏联合甲硝唑凝胶在预防种植牙术后感染中的临床疗效。方法选择2016年1月-2016年12月于医院行因牙列缺损而行牙齿种植修复的患者100例为研究对象,随机分为全身组与局部组各50例。全身组患者术后口服头孢克洛胶囊和甲硝唑片;局部组患者术后种植手术缝合前种植窝洞及切口局部涂用盐酸米诺环素软膏,甲硝唑凝胶。术后7天评价临床疗效,治疗后2天采用视觉模拟评分法对疼痛情况评分,比较治疗前后两组PCT与CRP水平。结果局部组患者显效29例占58.0%,全身组患者显效23例占46.0%,局部组患者临床疗效优于全身组患者(Z=7.180,P=0.028);治疗后,局部组患者疼痛分级为0级的有30例占60.0%,全身组患者0级的有19例占38.0%,局部组患者疼痛分级优于全身组患者(Z=3.225,P=0.044)。结论种植牙术后采用盐酸米诺环素软膏联合甲硝唑凝胶局部用药预防术后感染能够达到更好的临床效果。

OBJECTIVE To discuss the clinical efficacy of minocycline hydrochloride combined with metronidazole gel topical medication for prevention of postoperative infections of dental implants.METHODS A total of 100 cases of patients with dental implants from Jan.2016 to Dec.2016 were selected and randomly divided into systemic medication group and topical medication group,with 50 cases in each group.The systemic medication group was treated with cefaclor capsules and metronidazole tablets after dental implants,and the topical medication was treated with minocycline hydrochloride combined with metronidazole gel topical medication after dental implants.The clinical efficacy was evaluated 7 days after operation.The visual analogue scale was used 2 days after treatment to assess the pain.PCT and CRP levels before and after treatment of the two groups were compared.RESULTSIn the topical medication group,29 cases were markedly effective,accounting for 58.0%,while 23 cases in the systemic medication group,accounting for 46.0%,and the clinical effect of the topical medication group was significantly better than that of the systemic medication group（Z=7.180,P=0.028）.After treatment,the pain classification of0 in topical medication group was 30 cases,accounting for 60.0%,while 19 cases in the systemic medication group,accounting for 38.0%,and classification of pain in the topical medication group was significantly better than that in the systemic medication group（Z=3.225,P=0.044）.CONCLUSION Minocycline hydrochloride combined with metronidazole gel topical medication for prevention of postoperative infections of dental implants shows good clinical efficacy.