骨骼肌脂肪异位沉积在高脂膳食诱导胰岛素抵抗中的作用

Role of skeletal muscle fat ectopic deposition in insulin resistance induced by high-fat diet

高脂膳食会引起机体摄入脂肪的增加,导致人体内过量的脂肪储存,甚至超过人体脂肪组织的储存能力,造成脂肪的异位沉积,即在肝脏和骨骼肌等糖代谢的重要组织积累。最近的研究表明,与肥胖相比,骨骼肌脂肪含量与胰岛素抵抗的发生相关性更高。骨骼肌是最大的糖代谢场所,约80%～90%的2型糖尿病的发病原因为骨骼肌胰岛素抵抗。因此,骨骼肌脂肪含量与胰岛素抵抗之间的关系成为最近研究的热点,本文综述了高脂膳食引起骨骼肌脂肪异位沉积,进而诱导产生骨骼肌胰岛素抵抗的主要机制的研究进展。

Consumption of high-fat diet leads to the increase of fat intake and consequent excess storage of fat in the body. When the regular adipose tissues reach their capacity to store fat, ectopic fat is stored around and within non-adipose tissues, such as the liver and skeletal muscle, which plays important roles in glucose metabolism. Hence ectopic fat accumulation in major insulin target tissues is a critical determinant of insulin resistance （IR） and various related metabolic syndromes. Recent studies have shown that skeletal muscle lipid accumulation is more closely related with IR than general obesity and accounts for approximately 80%-90% type 2 diabetes, since the skeletal muscle is the largest glucose disposal site. Therefore, the association between skeletal muscle lipid and IR has attracted more and more research interest. This review summarized diet and its possible mechanisms. the role of ectopic skeletal muscle lipid in IR induced by high-fat