降糖药物对2型糖尿病患者心力衰竭的影响

Effect of hypoglycemic drugs on heart failure in type 2 diabetic patients

众多降糖药物依照美国食品和药品管理局(FDA)规范启动了大型前瞻性心血管安全性试验,目前已有超过20项试验报道了2型糖尿病(T2DM)患者的主要心血管预后,而且还有许多随机对照试验正在进行中。本文通过检索国内外各大数据库中降糖药的心血管安全性相关文献,分析发现T2DM患者的心血管事件和心力衰竭(HF)风险显著增加,并且不同降糖药物对HF风险的影响具有明显的异质性。

Numerous hypoglycemic agents have launched large-scale prospective cardiovascular safety tests in accordance with the US Food and Drug Administration（FDA）regulations.More than 20 trials have reported the major cardiovascular outcomes in patients with T2 DM,and there are many randomized controlled trials.In this article,we searched the literature on the cardiovascular safety of hypoglycemic agents in major databases at home and abroad and found that the risk of cardiovascular events and heart failure（HF）increased significantly in patients with type 2 diabetes,and the risk of heart failure was different for different hypoglycemic drugs.