中性粒细胞淋巴细胞比值在筛查扩张型心肌病心力衰竭患者中的作用

Screening value of neutrophil to lymphocyte ratio in patients with heart failure caused by dilated cardiomyopathy

目的:探究外周血中性粒细胞淋巴细胞比值(NLR)对扩张型心肌病(DCM)心力衰竭(心衰)患者的诊断价值。方法:收集从2015-09-2017-12DCM心衰患者264例和健康对照236例,分析两组间NLR差异性,并探究NLR与DCM心衰患者NYHA分级的关系。通过ROC曲线评估NLR对DCM心衰患者的诊断价值。结果:DCM心衰患者的NLR(2.92±1.44)明显高于健康对照组的NLR(1.65±0.51),且随着DCM心衰患者NYHA分级水平的升高,NLR值明显升高(P<0.001)。应用ROC曲线分析,NLR的曲线下面积为0.809(95%CI:0.772~0.846),计算出的截断值为1.94,敏感度特异度分别为73.1%、75.0%。NLR>1.94可作为DCM心衰患者的筛查依据。结论:NLR与DCM患者心衰的严重程度有关。

Objective：To investigate the screening value of peripheral blood neutrophil to lymphocyte ratio（NLR）inpatients with heart failure（HF）due to dilated cardiomyopathy（DCM）.Method：A total of 264 patients with DCM-HF were recruited from September 2015 to December 2017,with 236 healthy individuals as the control group.The NLR between DCM-HF patients and healthy controls were analyzed,and its diagnostic value was evaluated using the ROC curve.Besides,we assessed the relationship between NLR levels and New York Heart Association（NYHA）functional classes in patients with DCM-HF.Result：The NLR of DCM-HF patients was 2.92±1.44 and healthy controls was 1.65±0.51.As NYHA functional classes increased,NLR（P0.001）also increased significantly.The NLR cutoff value predicting DCM-HF was 1.94 with 73.1% sensitivity and 75.0% specificity;the area under the curve for DCM-HF was 0.809（95%CI：0.772-0.846）.Conclusion：NLR is associated with the severity of chronic heart failure in DCM-HF.